Investigating the role of sTREM in outcomes after thrombectomy for stroke
Official title: Soluble Soluble Triggering Receptors Expressed on Myeloid Cells (sTREM) Predict Outcomes in Stroke Patients Receiving Endovascular Thrombectomy
Run by The Affiliated Hospital of Xuzhou Medical University · NCT06545591 · Data updated 2026-11-12
This study is trying to see if certain proteins in the blood can help predict how well people recover after a procedure to remove a blood clot from their brain during a stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | The Affiliated Hospital of Xuzhou Medical University Academic / other |
| Locations | 1 site (Xuzhou, Jiangsu) |
| Status | Recruiting |
| Started | July 1, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | August 9, 2024 |
| Trial ID | NCT06545591 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old with acute large vessel occlusion who are scheduled to receive endovascular treatment within 24 hours of symptom onset.
✕Probably not a fit
Patients who are unable to provide blood samples or those who refuse informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the prognostic significance of soluble triggering receptors expressed on myeloid cells (sTREM1 and sTREM2) in patients with acute ischemic stroke who undergo endovascular thrombectomy (EVT). By analyzing blood samples taken before and after the procedure, the study seeks to establish a correlation between sTREM levels and functional outcomes at three months post-stroke. The research will also include non-stroke controls and patients who did not receive EVT to provide a comprehensive understanding of sTREM's role in stroke recovery.
Why it matters
Potential benefit: If successful, this study could help identify biomarkers that predict recovery outcomes for stroke patients undergoing thrombectomy.
How similar studies have gone: While the role of sTREM in stroke outcomes is being explored, this specific approach appears to be novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \> 18 years old. * Patients with acute large vessel occlusion within 24 hours of onset who will receive endovascular treatment. Exclusion Criteria: * Impossibility of getting a blood sample. * Impossibility of performing the test (Invalid results). * Refusal to provide the informed consent by the patient/relative.
Where it's running
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Department of Neurology
Xuzhou, Jiangsu, China Recruiting
Study contacts
- Study coordinator: Xingzhi Wang, MD
- Email: wxz1220@126.com
- Phone: 0086-13852000759
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.