Clinical trial Recruiting at 4 sites Interventional Ages 18 and up

Dual Stentriever Approach in Acute Ischemic Stroke with Large Vessel Occlusion

Official title: DUAL VERSUS SINGLE STENTRIEVER FOR RECANALIZATION IN ACUTE ISCHEMIC STROKE: THE RANDOMIZED DOUBLE UP TRIAL

Run by Instituto de Investigación Marqués de Valdecilla · NCT07113184 · Data updated 2026-11-12

This study tests whether using two stentrievers together helps people with a large vessel stroke in the front part of the brain.

More Acute Ischemic Stroke trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment220 (estimated)
SponsorInstituto de Investigación Marqués de Valdecilla
Academic / other
Locations4 sites (Burgos and 3 other locations)
StatusRecruiting
StartedMarch 1, 2026
Main results expectedMarch 1, 2027
Study endsDecember 31, 2027
Registry record updatedNovember 10, 2026
Trial IDNCT07113184 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18 and older with anterior circulation large vessel occlusion, NIHSS ≥ 6, ASPECTS > 6, and favorable pre-stroke disability (mRS ≤ 1).

Probably not a fit

Patients without large vessel occlusion, posterior circulation strokes, or significant contraindications may not benefit from this approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants are adults with acute ischemic stroke due to proximal anterior circulation occlusion. The study compares a dual stentriever approach to a single stentriever strategy during mechanical thrombectomy. Outcomes focus on blood flow restoration and early functional status, aiming to generate high-quality evidence to inform guidelines. Key eligibility includes moderate-to-severe initial stroke symptoms, reasonable brain tissue viability, and consent for participation. The trial is conducted across three Spanish hospitals and is designed to reflect real-world interventional practice.

Why it matters

Potential benefit: If successful, the dual stentriever approach could improve clot removal and functional recovery after stroke.

How similar studies have gone: Prior studies with similar endovascular methods have shown benefits in clot retrieval; this trial tests whether adding a second stentriever provides additional advantage.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥ 18
* NIHSS ≥ 6
* mRS ≤ 1
* Proximal anterior circulation occlusion
* ASPECTS \> 6
* Informed consent

Exclusion Criteria:

* Absence of occlusion
* Posterior circulation stroke
* Carotid dissection or tandem stenosis requiring treatment
* Severe comorbidities or contraindications to imaging contrast

Where it's running

  • Hospital de Burgos
    Burgos, Spain
    Recruiting
  • Hospital Regional de Málaga
    Málaga, Spain
    Recruiting
  • Complejo Hospitalario de Salamanca
    Salamanca, Spain
    Recruiting
  • Hospital universitario marques de valdecilla
    Santander, Spain
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.