Dual Stentriever Approach in Acute Ischemic Stroke with Large Vessel Occlusion
Official title: DUAL VERSUS SINGLE STENTRIEVER FOR RECANALIZATION IN ACUTE ISCHEMIC STROKE: THE RANDOMIZED DOUBLE UP TRIAL
Run by Instituto de Investigación Marqués de Valdecilla · NCT07113184 · Data updated 2026-11-12
This study tests whether using two stentrievers together helps people with a large vessel stroke in the front part of the brain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | Instituto de Investigación Marqués de Valdecilla Academic / other |
| Locations | 4 sites (Burgos and 3 other locations) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | March 1, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | November 10, 2026 |
| Trial ID | NCT07113184 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 and older with anterior circulation large vessel occlusion, NIHSS ≥ 6, ASPECTS > 6, and favorable pre-stroke disability (mRS ≤ 1).
✕Probably not a fit
Patients without large vessel occlusion, posterior circulation strokes, or significant contraindications may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants are adults with acute ischemic stroke due to proximal anterior circulation occlusion. The study compares a dual stentriever approach to a single stentriever strategy during mechanical thrombectomy. Outcomes focus on blood flow restoration and early functional status, aiming to generate high-quality evidence to inform guidelines. Key eligibility includes moderate-to-severe initial stroke symptoms, reasonable brain tissue viability, and consent for participation. The trial is conducted across three Spanish hospitals and is designed to reflect real-world interventional practice.
Why it matters
Potential benefit: If successful, the dual stentriever approach could improve clot removal and functional recovery after stroke.
How similar studies have gone: Prior studies with similar endovascular methods have shown benefits in clot retrieval; this trial tests whether adding a second stentriever provides additional advantage.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 * NIHSS ≥ 6 * mRS ≤ 1 * Proximal anterior circulation occlusion * ASPECTS \> 6 * Informed consent Exclusion Criteria: * Absence of occlusion * Posterior circulation stroke * Carotid dissection or tandem stenosis requiring treatment * Severe comorbidities or contraindications to imaging contrast
Where it's running
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Hospital de Burgos
Burgos, Spain Recruiting -
Hospital Regional de Málaga
Málaga, Spain Recruiting -
Complejo Hospitalario de Salamanca
Salamanca, Spain Recruiting -
Hospital universitario marques de valdecilla
Santander, Spain Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.