Circadian factors shaping reperfusion success in acute stroke
Official title: Circadian regulation of reperfusion efficacy in acute ischemic stroke
Funded at Massachusetts General Hospital · NIH-11389678 · Data updated 2026-11-12
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 11, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $648,672 |
| NIH project number | 1R01NS149686-01 |
| Project ID | NIH-11389678 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with acute ischemic stroke eligible for reperfusion therapy and undergoing imaging/biomarker assessments.
✕Less likely to help
Patients not undergoing reperfusion or without access to advanced imaging/biomarker analysis may see limited direct benefit.
What this research studies
We will study whether the time of day and related circadian biology affect outcomes after reperfusion in acute ischemic stroke. The project uses patient brain imaging and biomarkers, plus mouse stroke models, to explore tissue viability and blood flow changes across different times of day. By understanding circadian influences, we may identify when reperfusion works best and whether timing or targeted therapies could improve results for patients with large brain injury cores.
Why it matters
Potential benefit: If successful, findings could help tailor reperfusion timing or adjunct therapies to improve recovery after stroke.
How similar studies have gone: Preclinical data suggest circadian timing affects stroke injury and treatment responses, with some translational work indicating potential benefits of timing considerations.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Lo, Eng H. — Massachusetts General Hospital
- Study coordinator: Lo, Eng H.
Related research
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-
Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
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A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
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Engineered tissue regulatory T cells as a treatment for stroke
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Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
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A practical brain-cooling device to protect the brain during acute ischemic stroke
A new, patient-friendly endovascular cooling system aims to protect brain tissue during emergency stroke treatment to improve recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.