Evaluating brain metabolism in minor strokes with large vessel occlusion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the evolution of acute minor strokes caused by large vessel occlusion using magnetic resonance spectroscopic imaging (MRSI). It focuses on identifying neurometabolic predictors of early neurological deterioration and functional outcomes, as well as examining the dynamic changes of neurotransmitters and neurometabolites over time. Patients diagnosed with acute mild ischemic stroke will undergo MRSI scans at various stages: acute (within 24 hours), subacute (5-7 days), and chronic (90 days). The study seeks to understand how these metabolic changes correlate with neurological outcomes, potentially guiding treatment decisions for at-risk patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult (age ≥ 18 years) patients presenting with symptoms consistent with acute ischemic stroke due to occlusion of the intracranial internal carotid artery and/or M1 or M2 segment of the middle cerebral artery;
2. Patients with mild symptoms at admission (National Institutes of Health Stroke Scale (NIHSS)\<6);
3. Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital;
4. Time from symptom onset or last known normal to enrollment is less than 24 hours;
5. Patient or legal representative willing to comply with protocol requirements and data collection procedures, understand and sign informed consent.

Exclusion Criteria:

1. A pre-incident mRS ≥ 1 point before onset;
2. Previous clear history of cerebral infarction, cerebral hemorrhage, brain tumor and other diseases that affect cerebral metabolism;
3. Intolerance or non-cooperation with magnetic resonance examination;
4. Severe cardiac, hepatic, renal impairment or other systemic serious advanced diseases;
5. Pregnancy or lactation;
6. Life expectancy is less than 3 months;
7. Other conditions that, in the opinion of the investigator, are not suitable for participation in this study or may pose a significant risk to the patient (such as inability to understand and/or comply with study procedures and/or follow-up due to psychiatric disorders, cognitive or emotional disorders).

Where it's running

• Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Li Cao, phD — Shanghai Jiao Tong University Affiliated Sixth People's Hospital
• Study coordinator: Li Cao, phD
• Email: caoli2000@yeah.net
• Phone: +86 21 64369263

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.