Identifying biomarkers for early detection of acute stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on adult patients presenting to emergency departments with suspected acute stroke within 24 hours of symptom onset. The research aims to identify specific biomarkers in blood and saliva that can aid in the early detection, diagnosis, and prognosis of various types of strokes. By analyzing these biomarkers, the study seeks to develop and validate models that can improve the accuracy and speed of stroke diagnosis. The ultimate goal is to enhance patient outcomes through timely and precise medical intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients eligible for enrolment include:

  * Adults ≥18 years of age.
  * Suspected acute stroke. Defined as either FAST-positive, or LAPSS-positive or ROSIER\>0
  * Within 24 hours of symptom onset.
  * Informed consent.
* Control subjects will be drawn from two groups:

  * Non-neurologic patients who are matched with TIA and stroke cases (AIS, HS) for age, race, gender and smoking plus one or more of the following vascular risk factors: diabetes, hypertension, atrial fibrillation, hyperlipidaemia.
  * Relatives or accompanying friends.
* Note that we will include and collect samples from the following cases if they present as suspected stroke and are recruited \<24 hours from symptom onset.

  * Any central nervous system infection, i.e. meningitis or encephalitis in the past 30 days
  * Any form of head trauma, stroke or intracranial haemorrhage in the past 30 days
  * Known primary or metastatic cancer involving the brain
  * Active cancer is defined as a diagnosis of cancer, within 6 months before enrollment, any treatment for cancer within the previous 6 months, or recurrent or metastatic cancer.
  * Autoimmune diseases: such as lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis
  * Active infectious diseases (e.g. HIV/AIDS, hepatitis C)
  * Major surgery within three months prior to the index event

Exclusion Criteria:

* Clear onset of acute symptoms \>24 hours.

Where it's running

• Hong Kong University
  Hong Kong, China Recruiting

Study contacts

• Principal investigator: Timothy H Rainer, MD — The University of Hong Kong
• Study coordinator: Timothy H Rainer, MD
• Email: thrainer@hku.hk
• Phone: +852 39176846

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Assessing treatment strategies for stroke patients with atrial fibrillation

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• Early rhythm-control therapy for stroke patients with atrial fibrillation

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  Recruiting Phase 3 Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT05293080

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

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• Short-Term outside-in nerve stimulation for acute ischemic stroke

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• Sevoflurane vs. Propofol for anesthesia in stroke patients undergoing clot-removal

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  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT07902791

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.