Investigating a new treatment for acute ischemic stroke using a specific inhibitor.
Soluble Epoxide Hydrolase Inhibitor GSK2256294 for Acute Ischemic Stroke
['FUNDING_U01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11042219
This study is looking at how a medication called GSK2256294 might help protect the brain during a stroke by boosting helpful substances that reduce damage and improve blood flow, and it's for both younger and older patients, including those with diabetes and high blood pressure.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11042219 on ClinicalTrials.gov |
What this research studies
This research focuses on the effects of GSK2256294, an FDA-approved soluble epoxide hydrolase inhibitor, on protecting the brain during acute ischemic stroke. The study aims to increase levels of beneficial brain lipid mediators that can help reduce brain damage, inflammation, and improve blood flow. By examining the outcomes in both young and older patients, including those with diabetes and hypertension, the research seeks to establish the efficacy and safety of this treatment in a clinical setting. Previous trials have shown promise, indicating that this approach could lead to better recovery outcomes for stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced an acute ischemic stroke, particularly those with underlying conditions like diabetes or hypertension.
Not a fit: Patients who have not experienced an acute ischemic stroke or those with contraindications to the treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and recovery outcomes for patients suffering from acute ischemic stroke.
How similar studies have performed: Previous research has shown promising results with similar approaches, indicating potential for significant advancements in stroke treatment.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALKAYED, NABIL J — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: ALKAYED, NABIL J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, adult onset diabetes, Adult-Onset Diabetes Mellitus