Investigating how endothelial cell fat metabolism affects outcomes after a stroke
Defining the contribution from endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice
This study is looking at how fat in brain cells affects recovery after a stroke, and it aims to find out if lowering certain fat molecules can help improve healing and movement for people who have had a stroke.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11073799 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of fat metabolism in brain cells during acute ischemic stroke (AIS), a condition that can lead to severe neurological impairments. Using mouse models, the study aims to explore whether targeting specific fat molecules in brain endothelial cells can improve recovery after a stroke. The researchers will test new treatments that lower these fat molecules to see if they can reduce brain damage and improve motor function. By analyzing the effects of these interventions, the study seeks to provide insights into potential therapies for stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an acute ischemic stroke and are seeking innovative treatment options.
Not a fit: Patients who have not experienced a stroke or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and quality of life for stroke survivors.
How similar studies have performed: While this approach is innovative, previous studies have shown that targeting metabolic pathways in brain cells can lead to improved outcomes in other neurological conditions.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Symons, John David — University of Utah
- Study coordinator: Symons, John David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.