Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
Official title: Modeling of Acute Ischemic Stroke for Improving Mechanical Thrombectomy
Funded at Pennsylvania State University, the · NIH-11464942 · Data updated 2026-11-12
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | May 4, 2020 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $777,870 |
| NIH project number | 2R01HL146921-05 |
| Project ID | NIH-11464942 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include patients with acute ischemic stroke who may be treated with thrombectomy and have available imaging or emboli samples for research correlation.
✕Less likely to help
Patients not undergoing thrombectomy or without access to compatible data or samples may not directly benefit.
What this research studies
This project uses pig models and lab tests to study arterial injury, distal clot spread, and how clot‑busting drugs affect treatment. It also collects patient data such as anatomy and retrieved clots to validate and refine a computational platform. The goal is to provide a validated, patient‑relevant tool to guide the development of next‑generation thrombectomy devices and therapies. If successful, these models could streamline device design and potentially improve outcomes for stroke patients.
Why it matters
Potential benefit: Could speed the development of safer, more effective clot‑removal devices and therapies for stroke patients.
How similar studies have gone: Previous modeling and animal studies have helped understand thrombectomy mechanics, with ongoing work showing promise for improved device design.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Manning, Keefe B — Pennsylvania State University, the
- Study coordinator: Manning, Keefe B
Related research
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Improving treatment for acute ischemic stroke using advanced modeling techniques
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Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
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Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.