Understanding how heart conditions contribute to strokes
Official title: Defining the role of Atrial Cardiopathy and Subclinical Cardiac Disease in Acute Ischemic Stroke
Funded at Johns Hopkins University · NIH-10897041 · Data updated 2026-11-12
This study is looking at how certain heart problems might affect recovery after a stroke, and it's for people who have had an acute ischemic stroke to help improve their care and outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 15, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $193,860 |
| NIH project number | 5K23NS112459-05 |
| Project ID | NIH-10897041 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an acute ischemic stroke and may have underlying heart conditions.
✕Less likely to help
Patients who have not experienced a stroke or do not have any cardiac conditions may not benefit from this research.
What this research studies
This research investigates the relationship between heart conditions, specifically atrial cardiopathy and subclinical cardiac disease, and their role in acute ischemic strokes. By using advanced imaging techniques, the study aims to identify specific cardiac markers that may predict long-term outcomes for stroke patients. The goal is to improve patient care by better understanding how these heart conditions affect stroke risk and recovery. Patients with acute ischemic stroke will be evaluated to see how their cardiac health influences their recovery and overall health.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and treatment of heart conditions that increase stroke risk, ultimately enhancing patient outcomes.
How similar studies have gone: Previous research has shown promise in identifying cardiac conditions related to stroke risk, but this study aims to refine and expand upon those findings.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Johansen, Michelle C. — Johns Hopkins University
- Study coordinator: Johansen, Michelle C.
Related research
Other NIH-funded projects on the same topics.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
-
Nanoparticle-delivered tPA to overcome clot resistance in acute ischemic stroke
A Mayo Clinic team is testing a nanoparticle-delivered tPA approach to help dissolve clots more effectively in people with acute ischemic stroke due to large vessel blockage.
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Engineered tissue regulatory T cells as a treatment for stroke
A new off-the-shelf cell therapy using engineered regulatory T cells could help people who have an ischemic stroke recover by reducing inflammation and promoting tissue repair.
-
Fast penumbral imaging to guide stroke treatment
Aims to develop quick MRI techniques to identify tissue at risk in acute ischemic stroke and help decide whether to use advanced clot-busting treatment.
-
Circadian factors shaping reperfusion success in acute stroke
This grant looks at how the body’s internal clock might influence how well stroke patients respond to clot-busting or clot-removal treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.