Understanding how to apply sepsis care guidelines in ICU patients with respiratory failure
Official title: Assessment of Implementation Methods in Sepsis and Respiratory Failure
Funded at Rhode Island Hospital · NIH-11393914 · Data updated 2026-11-12
A patient-friendly look at how hospitals can best use sepsis care bundles to save lives for people with breathing problems in the ICU.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $544,334 |
| NIH project number | 5R01HL162954-05 |
| Project ID | NIH-11393914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Hospitals and ICU teams caring for adults with sepsis or respiratory failure, with an interest in improving guideline adherence.
✕Less likely to help
Direct patient benefit may be limited for individuals not managed under ICU sepsis protocols or outside hospital settings.
What this research studies
This grant examines how to put sepsis care guidelines into practice in ICUs, focusing on patients with respiratory infections or respiratory failure. Researchers will analyze implementation methods and real-world adherence to the sepsis bundles to see what helps care teams follow the guidelines more consistently. The work builds on evidence that following the bundles improves survival and aims to identify strategies that support quick, effective treatment. The findings could inform hospital policies and training to improve outcomes for people with sepsis-related respiratory failure.
Why it matters
Potential benefit: If successful, patients with sepsis and respiratory failure could receive faster, more consistent care that lowers the risk of death.
How similar studies have gone: Previous analyses linked timely bundle completion with lower mortality, supporting the potential impact of improved implementation.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Levy, Mitchell M — Rhode Island Hospital
- Study coordinator: Levy, Mitchell M
Related research
Other NIH-funded projects on the same topics.
-
Understanding which patients and hospital care pathways affect outcomes after ICU vs ward care for ARF and sepsis
A big study using hospital records to figure out which patients with acute respiratory failure and sepsis do best when admitted to ICUs versus general wards.
-
Understanding how care decisions affect outcomes for patients with breathing problems and sepsis
This project looks at hospital records to understand how decisions about where patients with severe breathing issues and sepsis receive care affect their recovery.
-
Improving sepsis care for patients with breathing failure
This project tries new ways to help hospitals deliver sepsis treatments faster for people with sepsis or acute respiratory failure.
-
Understanding the risks of acute respiratory failure in patients with hospital-onset sepsis
This study looks at how patients with hospital-onset sepsis might face different chances of developing breathing problems, and it aims to find better ways to treat those at higher risk so they can get the care they need to feel better.
-
Understanding why critically ill patients with respiratory failure and sepsis face health disparities.
This study is looking into why critically ill patients with breathing problems and infections, especially those from minority backgrounds, often have worse health outcomes, and it aims to find ways to improve their care based on their unique challenges.
-
Understanding how ICU and ward care affects patients with severe respiratory issues and sepsis
This study looks at how choosing to treat patients with serious breathing problems and infections in either intensive care units or regular hospital rooms affects their recovery, with the aim of finding ways to improve care for these patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.