Imaging how belly fat affects lung collapse in severe breathing failure

Who could benefit from this research

What this research studies

This project will enroll patients with acute hypoxemic respiratory failure and use advanced CT imaging and AI-based analysis to map truncal adiposity and its effects on intrathoracic pressure and lung collapse. By comparing imaging findings with clinical responses to treatments like prone positioning and PEEP, the team aims to identify imaging markers that reflect severity and guide therapy at the bedside. The work builds on prior methods that quantify lung injury and collapse using CT registration and segmentation powered by artificial intelligence. The goal is to improve understanding of obesity-related differences in AHRF and to develop practical imaging tools that clinicians can use to tailor care.

Why it matters

Where this research is happening

• Massachusetts General Hospital
  Boston, United States Active

Researchers

• Principal investigator: Cereda, Maurizio Franco — Massachusetts General Hospital
• Study coordinator: Cereda, Maurizio Franco

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.