How different oxygen targets and interfaces affect oxygen flow in patients needing supplemental oxygen
Official title: Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates
Run by Laval University · NCT06646991 · Data updated 2026-11-12
This study tests how the oxygen delivery interface (nasal cannula at various flow rates, open mask, or simple mask) and SpO2 target settings influence the amount of oxygen flow patients require.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Laval University Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Status | Recruiting |
| Started | November 27, 2024 |
| Main results expected | June 2027 |
| Study ends | December 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT06646991 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years and older on conventional oxygen therapy with SpO2 between 88% and 100% using the usual oximeter and with SpO2 dropping below 92% in ambient air.
✕Probably not a fit
Patients who do not meet the SpO2 criteria or require higher oxygen flows (>6 L/min) may not benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will examine whether using different oxygen targets and oximeters changes the required oxygen flow in adults on conventional oxygen therapy. They will also explore whether certain interfaces, especially closed oxygen masks, affect carbon dioxide levels (PaCO2) due to potential rebreathing. The study will compare multiple familiar interfaces to see how flow rates vary across patient groups. Primary focus is on how interface choices impact oxygen use, with a secondary look at PaCO2. Participation is limited to adults receiving oxygen therapy with specific SpO2 criteria.
Why it matters
Potential benefit: If successful, the findings could guide clinicians to optimize oxygen delivery, potentially reducing unnecessary oxygen use and improving patient safety.
How similar studies have gone: Previous observations suggest that different interfaces and SpO2 targets can modify oxygen flow needs, but the combined effect across interfaces is not yet well defined.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult (\> or = 18 years old) * Ongoing on conventional oxygen therapy with peripheral oxygen saturation (SpO2) between 88 and 100% with the usual oximeter * SpO2 \< 92% ambient air with the usual oximeter Exclusion Criteria: * No SpO2 signal with with the usual oximeter * False nails or nail polish * Severe anemia documented on last blood count during current hospitalization (haemoglobin (Hb) \< 80g/L) * Oxygen flow \> 6 L/min
Where it's running
-
Insitut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval
Québec, Quebec, Canada Recruiting
Study contacts
- Study coordinator: François Lellouche
- Email: françoislellouche@criucpq.ulaval.ca
- Phone: 1-418-656-8711
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.