Using Ganciclovir to Prevent Cytomegalovirus Reactivation in Patients with Severe Respiratory Issues

Who could benefit from this research

What this research studies

This research investigates the use of ganciclovir, an antiviral medication, to prevent the reactivation of cytomegalovirus (CMV) in patients suffering from acute respiratory failure due to sepsis. CMV can reactivate during critical illness, leading to worse outcomes, and this study aims to determine if ganciclovir can effectively suppress this reactivation. The approach involves administering ganciclovir to CMV seropositive adults and monitoring their clinical outcomes, including the duration of mechanical ventilation and ICU stay. The research builds on previous findings that suggest ganciclovir may improve recovery in these patients.

Why it matters

Where this research is happening

• Fred Hutchinson Cancer Center
  Seattle, United States Active

Researchers

• Principal investigator: Boeckh, Michael J — Fred Hutchinson Cancer Center
• Study coordinator: Boeckh, Michael J

Related research

Other NIH-funded projects on the same topics.

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  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11082526

• Understanding why critically ill patients with respiratory failure and sepsis face health disparities.

  This study is looking into why critically ill patients with breathing problems and infections, especially those from minority backgrounds, often have worse health outcomes, and it aims to find ways to improve their care based on their unique challenges.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11018640

• Understanding how ICU and ward care affects patients with severe respiratory issues and sepsis

  This study looks at how choosing to treat patients with serious breathing problems and infections in either intensive care units or regular hospital rooms affects their recovery, with the aim of finding ways to improve care for these patients.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10918227

• Using ganciclovir to stop cytomegalovirus from reactivating in patients with severe respiratory failure and sepsis

  This study is looking at whether the antiviral drug ganciclovir can help prevent a virus called cytomegalovirus (CMV) from coming back in adults who are seriously ill with respiratory failure from sepsis, and it’s for people who want to help improve treatment options for patients in critical condition.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10914214

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.