Readiness for EXtubation (REXs) score for patients on invasive mechanical ventilation
A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score (REXs STUDY)
This will test the Readiness for EXtubation (REXs) score to see if it can predict which ICU patients on invasive mechanical ventilation can be safely extubated.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 470 (estimated) |
| Ages | 18 Years to 89 Years |
| Sex | All |
| Sponsor | Medipol University Academic / other |
| Locations | 7 sites (Punta Arenas and 6 other locations) |
| Trial ID | NCT07098611 on ClinicalTrials.gov |
What this trial studies
This observational, multi-center study aims to develop and validate a multi-component Readiness for EXtubation (REXs) score using clinical parameters and spontaneous breathing trial results in patients undergoing weaning from invasive mechanical ventilation. The score will be derived and calibrated across participating ICUs, with extubation success defined as not requiring invasive mechanical support within 48 hours. Standard inclusion and exclusion criteria will be applied and sites will report findings following the STROBE guidance. Collected data will be used to test predictive performance and optimize score thresholds before broader validation.
Who should consider this trial
Good fit: ICU patients who are in the weaning process from invasive mechanical ventilation and meet readiness-for-extubation clinical criteria, excluding tracheostomized or pregnant patients, are ideal candidates.
Not a fit: Patients who are tracheostomized, pregnant, have diaphragmatic pacers, lack legal guardian consent, or are enrolled in other studies are not eligible and unlikely to benefit from this score.
Why it matters
Potential benefit: If successful, the REXs score could help clinicians reduce failed extubations and avoid unnecessary prolonged ventilation.
How similar studies have performed: Other multi-component weaning and extubation prediction scores and SBT-based approaches have been used with mixed success, so REXs builds on prior work but is not yet definitive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients who are in the weaning process from mechanical ventilation after being connected to invasive mechanical ventilation in the intensive care unit. Exclusion Criteria: * Patients without legal guardian consent. * Tracheostomized patients. * Patients enrolled in other studies. * Individuals with diaphragmatic pacers. * Pregnant patients.
Where this trial is running
Punta Arenas and 6 other locations
- University of Magallanes — Punta Arenas, Chile (Recruiting)
- Cairo University — Cairo, Egypt (Recruiting)
- Shahid Beheshti University of Medical Sciences — Tehran, Iran (Recruiting)
- A.O.R.N. "Dei Colli" Monaldi Hospital — Naples, Italy (Recruiting)
- Monaldi-Cotugno Hospital — Naples, Italy (Recruiting)
- Hospital General Universitario Morales Meseguer — Murcia, Spain (Recruiting)
- İstanbul Medipol University — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Berkan Basançelebi
- Email: berkan.basancelebi@medipol.edu.tr
- Phone: +90 444 8 544
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.