Condition

Acute Hypoxemic Respiratory Failure clinical trials and research

• 15Clinical trials
• 2NIH research projects
• 12Countries

Newest Acute Hypoxemic Respiratory Failure clinical trials

All recruiting trials (15)

• Predicting HFNC Failure in Acute Hypoxemic Respiratory Failure using Metabolomics and Clinical Data

  This study tests whether metabolomic blood profiles combined with routine clinical data can predict which adults with acute hypoxemic respiratory failure on high-flow nasal cannula will fail and need escalation of care.

  Recruiting Hospital del Mar Research Institute (IMIM) · Barcelona, Catalonia · NCT07607080

• Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure

  This study tests whether allowing spontaneous breathing or using controlled ventilation is better for adults with acute hypoxemic respiratory failure who need invasive mechanical ventilation.

  Recruiting Oslo University Hospital · Oslo, Oslo · NCT07463885

• IL-6 guided dexamethasone or tocilizumab treatment for hospitalized acute hypoxemic respiratory failure

  This study will test whether measuring IL-6 to guide early treatment with dexamethasone or tocilizumab helps adults hospitalized with new acute hypoxemic respiratory failure.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07334379

• How changing PEEP affects breathing drive and effort during pressure‑support ventilation

  We will test whether changing PEEP levels changes neural respiratory drive and inspiratory effort in adults on pressure‑support ventilation for moderate‑to‑severe ARDS or acute hypoxemic respiratory failure.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT07203781

• Intubation strategies for adults with acute hypoxemic respiratory failure

  This trial will test two different rules for when to intubate adults with acute hypoxemic respiratory failure to see which approach keeps patients safer while avoiding unnecessary mechanical ventilation.

  Recruiting University Hospital, Angers · Angers and 8 other locations · NCT07189078

• PEEP tuning in acute respiratory failure using CT and EIT data

  Researchers will look at routine CT and electrical impedance tomography data from adults on mechanical ventilation to see how different PEEP levels relate to lung information, without any new interventions.

  Recruiting Istituto Clinico Humanitas · Milan, Milan · NCT07175194

• Using Electrical Impedance Tomography to Optimize Ventilator Settings in Patients with Severe Breathing Problems

  This study is trying to see if using a special imaging technique can help set ventilators better for patients with severe breathing problems like acute respiratory failure.

  Recruiting Mahidol University · Bangkok · NCT06936618

• Using awake prone positioning for patients with acute hypoxic respiratory failure due to pneumonia

  This study is testing if having patients with pneumonia-related breathing problems lie on their stomachs while awake can help them breathe better and reduce the need for breathing tubes.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT06931938

• Using the Pressure-Muscle Index to avoid excessive ventilator support during pressure support ventilation

  This study will try using a Pressure-Muscle Index to find the right amount of pressure support for adults on mechanical ventilation for acute low-oxygen (hypoxemic) respiratory failure.

  Recruiting Università degli Studi di Trento · Trento, Trento · NCT06921655

• Comparing oxygen therapies for patients with acute respiratory failure

  This study is testing which of three oxygen therapies—CPAP, high-flow nasal oxygen, or non-invasive ventilation—works best to help adults with severe breathing problems avoid needing a breathing tube.

  Recruiting Southeast University, China · Nanjing, Jiangsu · NCT06795971

• Using a closed-loop oxygen controller for high flow oxygen treatment in critically ill adults

  This study is testing a new system that automatically adjusts oxygen levels for critically ill adults with breathing problems to see if it helps them breathe better than the usual method.

  Recruiting at 2 sites Başakşehir Çam & Sakura City Hospital · Istanbul and 1 other locations · NCT06374589

• Protocol for weaning patients off high-flow nasal oxygen therapy in intensive care

  This study is testing a new plan to help patients in intensive care who are on high-flow nasal oxygen therapy breathe on their own again by Day 7.

  Recruiting at 10 sites University Hospital, Tours · Blois and 10 other locations · NCT06104956

• Using a breathing support device to help patients with lung injury

  This study is testing if a new breathing support device can help people with lung injuries breathe better and get more oxygen.

  Recruiting at 3 sites NYU Langone Health · Brooklyn, New York and 3 other locations · NCT05675345

• Identifying subtypes of acute hypoxemic respiratory failure in emergency patients

  This study is trying to identify different types of acute respiratory failure in emergency patients to see how these types affect their chances of recovery and treatment options.

  Recruiting Evangelismos Hospital · Athens, Attica · NCT05150483

• Effects of music therapy on ICU patients on mechanical ventilation

  This study is testing if live music therapy can help ICU patients on mechanical ventilation breathe easier and recover faster.

  Recruiting at 3 sites Icahn School of Medicine at Mount Sinai · New York, New York and 2 other locations · NCT03642002

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Imaging how belly fat affects lung collapse in severe breathing failure

  A hospital-based study will use CT scans and AI tools to understand how truncal fat distribution changes lung collapse and treatment response in patients with acute hypoxemic respiratory failure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11408601

• Combination therapy with a helmet-style negative pressure system for acute breathing failure

  A new approach tests using high-flow oxygen together with a modern negative pressure device to help adults with acute hypoxemic breathing failure avoid invasive ventilation.

  NIH research New York University School of Medicine · New York, United States · NIH-11351229

Related topics

Quick answers

How many Acute Hypoxemic Respiratory Failure clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (2 trials), Italy (2 trials), France (2 trials), Norway (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →