How diaphragm strength changes during and after mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational program that will follow ICU patients who start invasive mechanical ventilation to measure diaphragm function over time. Investigators will use twitch transdiaphragmatic pressure recordings as the primary physiological measure, combined with cortical stimulation and diaphragm electromyography to probe neural contributions. Measurements will be repeated during mechanical ventilation and after extubation to track decline and potential recovery. Participants are enrolled early in ventilation (within 48 hours) and are expected to remain ventilated for at least five days.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Initiation of invasive mechanical ventilation in the Intensive Care Unit within 48 hours.
* Expected duration of invasive mechanical ventilation of at least 5 days.
* OR: elective bypass surgery with "planned" invasive mechanical ventilation

Exclusion Criteria:

* Body-mass-index (BMI) \>40
* Expected absence of active participation of the patient in study-related measurements after extubation
* Alcohol or drug abuse
* Non MRI compatible implant in the body
* Slipped disc
* Epilepsy
* Patients in an interdependence or with an employment contract with the principal investigator, Co-PI or his deputy.

Where it's running

• RWTH Aachen University
  Aachen, Germany Recruiting

Study contacts

• Principal investigator: Jens Spiesshoefer, MD — Department of Pneumology and Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
• Study coordinator: Michael Dreher, Professor
• Email: mdreher@ukaachen.de
• Phone: +4924180

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.