Condition

Hypoxemia clinical trials and research

• 17Clinical trials
• 14NIH research projects
• 20Countries

Newest Hypoxemia clinical trials

All recruiting trials (17)

• Melanin-Adjusted Blood Oxygen Sensor in ICU Patients

  This study tests a new pulse oximeter that adjusts for skin pigment to see if it gives accurate oxygen readings in ICU patients.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07799454

• HFNO vs. face mask for cerebral oxygenation during procedural sedation

  This randomized trial tests whether high-flow nasal oxygen helps maintain brain oxygenation better than a standard face mask during procedures done with sedation in adults.

  Recruiting Firat University · Elâzığ, Elâzığ · NCT07718295

• HFNC vs Microstream nasal cannula during ERCP

  This study compares high-flow nasal oxygen with the Microstream Advance nasal cannula to see which one better keeps patients’ oxygen levels stable during ERCP procedures done under deep sedation.

  Recruiting Kocaeli University · Kocaeli, Umuttepe · NCT07611903

• Extra oxygen during the 6-minute walk for people with chronic respiratory failure or exercise-related low oxygen

  This trial will test whether giving extra oxygen during a 6-minute walk helps people with chronic respiratory failure or exertional low oxygen from COPD or interstitial lung disease walk farther, breathe better, and feel easier during the test.

  Recruiting at 4 sites Istituti Clinici Scientifici Maugeri SpA · Lumezzane, Brescia and 5 other locations · NCT07451977

• Safety and performance of the INBENTUS VERSATILE ventilator in adults on invasive mechanical ventilation

  This trial will test whether the INBENTUS VERSATILE ventilator is safe and performs well in adults who need assisted or controlled invasive mechanical ventilation and short-term weaning.

  Recruiting Iconic Solutions By Murcia SL · Murcia · NCT07432191

• PIMUN to reduce low-oxygen episodes in preterm infants

  We will test whether PIMUN, a soft garment that gives gentle pulsatile dorsal stimulation, can reduce low-oxygen (SpO2 <90%) episodes in preterm infants born at 24–34 weeks who have apnea of prematurity.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago, Santiago Metropolitan and 1 other locations · NCT07396103

• COMBO airway plus high-flow nasal oxygen during sedated gastrointestinal endoscopy for morbidly obese adults

  This test will try combining the COMBO Endoscopy oropharyngeal airway with high-flow nasal oxygen to see if it reduces low-oxygen episodes during sedated gastrointestinal endoscopy in adults with BMI 35 or higher.

  Recruiting at 5 sites Zhejiang University · Beijing, Beijing Municipality and 4 other locations · NCT07175155

• Preventing oxygen drops during ERCP with nasal PAP or capnometry

  We'll try whether using nasal positive airway pressure or capnometry with low-flow oxygen during sedated ERCP reduces oxygen drops in adults receiving nurse-administered sedation.

  Recruiting at 2 sites Karl Landsteiner University of Health Sciences · Graz and 1 other locations · NCT07056075

• Inhaled Treprostinil (Tyvaso) for people with COPD and low oxygen

  This study will see if inhaled Treprostinil (Tyvaso) can increase lung blood flow and oxygen delivery in adults with COPD who have low oxygen levels.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT07037836

• Evaluating pulse oximeter accuracy in children with congenital heart disease

  This study is testing how accurate pulse oximeters are for children with congenital heart disease, especially looking at how skin color might affect their readings before surgery.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06575270

• Using driving pressure to improve lung ventilation after aortic dissection surgery

  This study is testing if a special way of helping patients breathe after aortic dissection surgery can lower the chances of low oxygen levels in their blood.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT06361420

• Monitoring breathing and activity after abdominal surgery

  This study is testing how breathing and activity tips can help people recover better after abdominal surgery by tracking their movements and breathing for a few days.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06239831

• Evaluating medical oxygen access and policies

  This study looks at how access to medical oxygen works in six countries to see what challenges people face and how to improve it for patients and healthcare providers.

  Recruiting at 6 sites Murdoch Childrens Research Institute · Phnom Penh and 5 other locations · NCT06169514

• Comparing different oximeters for measuring oxygen levels in ICU patients

  This study is testing how accurately different oximeters measure oxygen levels in ICU patients to see which ones give the best readings.

  Recruiting at 2 sites Laval University · Montreal, Quebec and 4 other locations · NCT06102499

• Evaluation of a multi-country medical oxygen program

  This study is trying to see how medical oxygen is used in hospitals across nine countries to find ways to make it easier for patients, especially children with low oxygen levels, to get the help they need.

  Recruiting Murdoch Childrens Research Institute · Phnom Penh and 2 other locations · NCT06087315

• Using awake prone positioning to improve respiratory failure treatment

  This study is testing if having patients with breathing problems lie on their stomach while awake can help them breathe better and reduce the need for a breathing tube.

  Recruiting Vilnius University · Kaunas and 3 other locations · NCT05990101

• Using ECMO to help patients with severe respiratory failure recover

  This study is testing if using a special breathing machine called ECMO along with regular ventilation can help patients with severe breathing problems recover faster and spend less time in intensive care.

  Recruiting at 6 sites Australian and New Zealand Intensive Care Research Centre · Darlinghurst, New South Wales and 6 other locations · NCT05562505

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Hypoxemia during Sleep in Sickle Cell Disease: How Common is It and How Might Treatments Help

  This study looks at how low oxygen during sleep affects adults with sickle cell disease and how they respond to therapy across multiple urban and rural sites.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11416641

• Novel alveolar factors driving low oxygen in liver-related lung disease

  A patient-focused study will explore how high bile acids in cirrhosis may harm tiny air sacs in the lungs, causing breathing problems in hepatopulmonary syndrome.

  NIH research University of Arizona · Tucson, United States · NIH-11401062

• Intermittent Hypoxemia in Early Life and Sleep in Preterm Children

  A study following school-age children who were born extremely preterm to understand how early breathing problems in the NICU relate to their sleep and health today.

  NIH research Northwestern University · Chicago, United States · NIH-11379517

• Predicting occult low oxygen events in adults with acute respiratory failure

  A small, patient-focused project aims to build a practical model to predict hidden low oxygen levels in adults with acute respiratory failure and understand what happens to them afterward.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11352884

• Postnatal low oxygen and heart immaturity impacting recovery after pediatric heart surgery

  Researchers will study how low oxygen levels after birth and immature heart cells affect recovery after heart surgery in children with congenital heart disease.

  NIH research Children's Research Institute · Washington, United States · NIH-11293548

• Understanding injury in preterm infants with low oxygen levels

  This study is looking at preterm babies who sometimes have low oxygen levels, and it aims to understand what causes harm to them and find new ways to help diagnose and treat these issues, all to improve their health and well-being.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11228708

• Dry powder lung surfactant aerosol for people with low oxygen or ARDS on breathing support

  This project is creating a dry powder lung surfactant you could inhale to help adults with low oxygen or ARDS who are on oxygen, noninvasive breathing support, or ventilators.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11145634

• How low oxygen levels during sleep affect muscle health in COPD patients

  This study is looking at how low oxygen levels during sleep might affect muscle health in people with COPD, helping us understand why some patients lose muscle strength and how a specific protein could play a role in keeping muscles healthy.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11052900

• Developing a new dry powder aerosol to help patients with severe breathing problems

  This study is testing a new dry powder treatment that can be turned into a mist to help people with breathing problems like hypoxemia or ARDS, and it aims to see if this treatment can reduce lung inflammation and work even better when combined with another medicine.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11020319

• Understanding the long-term effects of breathing issues in preterm infants

  This study is looking at how short episodes of low oxygen levels in preterm babies might impact their health as they grow up, especially concerning breathing problems like asthma and sleep issues, so we can find ways to help those babies early on for a healthier future.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11004618

• How low oxygen levels at night affect blood sugar during sleep in people living at high altitudes

  This study is looking at how low oxygen levels while you sleep might affect blood sugar control for people with sleep problems, especially those living at high altitudes, and it will also see if using extra oxygen at night can help improve blood sugar levels.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10916237

• Using bag-mask ventilation to prevent low oxygen levels during intubation in emergency situations.

  This study is looking at how well using a bag-mask to help patients breathe can prevent low oxygen levels during intubation in the emergency room, and it's aimed at helping critically ill adults who need breathing support.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10914977

• Developing a new dry powder aerosol treatment for lung issues in patients with respiratory distress

  This study is working on a new way to help people with serious breathing problems, like low oxygen levels or acute respiratory distress syndrome, by creating a dry powder that can be easily inhaled instead of using liquid treatments that can be harder to give.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10863857

• Finding ways to reverse breathing problems caused by opioids without losing pain relief.

  This study is looking at new medications that could help improve breathing in people who have taken too much fentanyl, while still managing their pain, and it's being tested in adult female goats to find safer options than the current antidote, naloxone.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-10118262

Related topics

Quick answers

How many Hypoxemia clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (4 trials), China (2 trials), Turkey (Türkiye) (2 trials), Cambodia (2 trials), Nigeria (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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