Improving sepsis care for patients with breathing failure
Official title: Assessment of Implementation Methods in Sepsis and Respiratory Failure
Funded at Rhode Island Hospital · NIH-11136405 · Data updated 2026-11-12
This project tries new ways to help hospitals deliver sepsis treatments faster for people with sepsis or acute respiratory failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $702,318 |
| NIH project number | 5R01HL162954-04 |
| Project ID | NIH-11136405 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with suspected sepsis from a respiratory infection, including those with acute respiratory failure or who may need mechanical ventilation and are treated at participating hospitals.
✕Less likely to help
People with sepsis from non-respiratory sources, those not treated at participating centers, or patients with mild infections not requiring urgent bundle care may not directly benefit from this project.
What this research studies
If you come to the hospital with sepsis that affects your breathing, this project focuses on making sure key treatments are given quickly. The team will test different methods hospitals use—such as clinician education, workflow changes, and targeted support—to increase timely completion of the Hour-1 and 3-Hour sepsis bundles for patients with respiratory infections or respiratory failure. They will use hospital and state data to track how quickly treatments are started and whether faster care leads to fewer ICU deaths and better survival. The goal is to find practical approaches that hospitals can adopt so patients receive life-saving sepsis care sooner.
Why it matters
Potential benefit: If successful, the work could lower deaths and improve recovery for patients with sepsis and respiratory failure by increasing how quickly lifesaving treatments are given.
How similar studies have gone: Observational studies and the New York State sepsis initiative have shown that faster bundle completion is linked to better survival, though testing specific implementation methods in prospective trials is more limited.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Levy, Mitchell M — Rhode Island Hospital
- Study coordinator: Levy, Mitchell M
Related research
Other NIH-funded projects on the same topics.
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Understanding how to apply sepsis care guidelines in ICU patients with respiratory failure
A patient-friendly look at how hospitals can best use sepsis care bundles to save lives for people with breathing problems in the ICU.
-
Understanding which patients and hospital care pathways affect outcomes after ICU vs ward care for ARF and sepsis
A big study using hospital records to figure out which patients with acute respiratory failure and sepsis do best when admitted to ICUs versus general wards.
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Understanding how care decisions affect outcomes for patients with breathing problems and sepsis
This project looks at hospital records to understand how decisions about where patients with severe breathing issues and sepsis receive care affect their recovery.
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Understanding the risks of acute respiratory failure in patients with hospital-onset sepsis
This study looks at how patients with hospital-onset sepsis might face different chances of developing breathing problems, and it aims to find better ways to treat those at higher risk so they can get the care they need to feel better.
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Understanding why critically ill patients with respiratory failure and sepsis face health disparities.
This study is looking into why critically ill patients with breathing problems and infections, especially those from minority backgrounds, often have worse health outcomes, and it aims to find ways to improve their care based on their unique challenges.
-
Understanding how ICU and ward care affects patients with severe respiratory issues and sepsis
This study looks at how choosing to treat patients with serious breathing problems and infections in either intensive care units or regular hospital rooms affects their recovery, with the aim of finding ways to improve care for these patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.