Improving sepsis care for patients with breathing failure
Assessment of Implementation Methods in Sepsis and Respiratory Failure
['FUNDING_R01'] · RHODE ISLAND HOSPITAL · NIH-11136405
This project tries new ways to help hospitals deliver sepsis treatments faster for people with sepsis or acute respiratory failure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RHODE ISLAND HOSPITAL (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11136405 on ClinicalTrials.gov |
What this research studies
If you come to the hospital with sepsis that affects your breathing, this project focuses on making sure key treatments are given quickly. The team will test different methods hospitals use—such as clinician education, workflow changes, and targeted support—to increase timely completion of the Hour-1 and 3-Hour sepsis bundles for patients with respiratory infections or respiratory failure. They will use hospital and state data to track how quickly treatments are started and whether faster care leads to fewer ICU deaths and better survival. The goal is to find practical approaches that hospitals can adopt so patients receive life-saving sepsis care sooner.
Who could benefit from this research
Good fit: Ideal candidates are patients with suspected sepsis from a respiratory infection, including those with acute respiratory failure or who may need mechanical ventilation and are treated at participating hospitals.
Not a fit: People with sepsis from non-respiratory sources, those not treated at participating centers, or patients with mild infections not requiring urgent bundle care may not directly benefit from this project.
Why it matters
Potential benefit: If successful, the work could lower deaths and improve recovery for patients with sepsis and respiratory failure by increasing how quickly lifesaving treatments are given.
How similar studies have performed: Observational studies and the New York State sepsis initiative have shown that faster bundle completion is linked to better survival, though testing specific implementation methods in prospective trials is more limited.
Where this research is happening
PROVIDENCE, UNITED STATES
- RHODE ISLAND HOSPITAL — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEVY, MITCHELL M — RHODE ISLAND HOSPITAL
- Study coordinator: LEVY, MITCHELL M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections