Condition

Cardiac Failure clinical trials and research

• 11Clinical trials
• 5NIH research projects
• 9Countries

Newest Cardiac Failure clinical trials

All recruiting trials (11)

• Heart remodeling after endovascular aortic repair

  We will see if endovascular aortic repair changes heart size, shape, or function in adults treated for aortic aneurysms or related aortic problems.

  Recruiting Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa · Lisbon and 1 other locations · NCT07415447

• Platelet population changes during ECMO circulatory support

  This will test whether the proportions of different platelet types change during ECMO in adults with cardiac or respiratory failure.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07334457

• Personalizing adult heart transplant immunosuppression using blood microRNA levels

  This project will try to use blood microRNA patterns to monitor immune status in adults after heart transplant and predict who will develop infection or rejection.

  Recruiting at 6 sites Northwestern University · Los Angeles, California and 5 other locations · NCT06939751

• Using Landiolol to improve outcomes in mitral valve surgery

  This study is testing if the medication Landiolol can help people having mitral valve surgery recover better and have fewer heart problems afterward.

  Recruiting at 13 sites Phase 4 Università Vita-Salute San Raffaele · Alessandria, Piedmont and 12 other locations · NCT06793670

• Social prescribing to help women with heart failure stick to treatments and avoid hospital visits.

  This project will try social prescribing—connecting women with heart failure to community supports—to help them take heart medicines and reduce hospitalizations.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec and 1 other locations · NCT06628973

• Identifying microRNAs to improve heart transplant outcomes in children

  This study is trying to find specific microRNAs in the blood of children who have had heart transplants to see if they can help predict infections and rejection of the new heart.

  Recruiting at 7 sites Northwestern University · Aurora, Colorado and 6 other locations · NCT06532890

• Effect of phosphocreatine on patients treated by medical emergency teams

  This study tests if giving phosphocreatine to hospitalized patients with serious conditions can help them recover faster and shorten their hospital stays compared to those who receive a placebo.

  Recruiting Phase 3 Università Vita-Salute San Raffaele · Milan · NCT06503016

• Optimizing beta-blocker use in older adults with heart failure

  This study is trying to see if a personalized approach to adjusting beta-blocker medication can help older adults with heart failure feel more confident in their treatment and manage their condition better.

  Recruiting Phase 4 Weill Medical College of Cornell University · New York, New York · NCT05585125

• Using xenon to protect the brain after aneurysmal subarachnoid hemorrhage

  This study is testing if inhaling xenon gas can help protect the brains of people who have had a brain bleed from an aneurysm.

  Recruiting Phase 2 Turku University Hospital · Helsinki, Helsinki and 6 other locations · NCT04696523

• Evaluating the safety and performance of the MOBYBOX System for heart and lung support

  This study is testing how safe and effective the MOBYBOX system is for helping patients with heart and lung failure.

  Recruiting at 4 sites Hemovent GmbH · Hanover, Lower Saxony and 3 other locations · NCT04183660

• Observing recovery from weakness after severe respiratory and cardiac failure

  This study looks at how people who had severe breathing and heart problems recover from weakness after being in intensive care and on a special life-support machine, to see what helps or hinders their recovery.

  Recruiting Barts & The London NHS Trust · London · NCT03753412

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Multicenter ECMO for Children: Cardiohelp System

  A multicenter study tests whether the Cardiohelp ECMO circuit can safely support children with severe heart failure for up to 30 days.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11563784

• A wearable monitor to detect worsening heart failure

  This project is creating a new wearable device to help heart failure patients and their doctors spot early signs of worsening heart failure from home.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11125919

• Creating a wearable device to monitor heart failure symptoms

  This study is testing a new wearable device that helps people with heart failure by spotting early signs of worsening health, so doctors can step in sooner and keep them out of the hospital.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10949969

• Investigating how DNA changes affect heart failure and recovery

  This study is looking at how changes in DNA might affect heart recovery for people with heart failure who are using special devices to help their hearts pump better, and it invites patients to share their information to help find new ways to improve heart health.

  NIH research University of Utah · Salt Lake City, United States · NIH-10871877

• Using the Cardiohelp System for life support in children with severe heart failure

  This study is looking at a special heart support device called the Cardiohelp system to see how well it works and keeps kids safe when they have serious heart problems and other treatments haven't worked, and it's for children aged 0 to 16 who need extra help for their hearts.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10861648

Related topics

Quick answers

How many Cardiac Failure clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (3 trials), Italy (2 trials), Portugal (1 trial), Finland (1 trial), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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