HFNC During Bronchoscopy for Respiratory Failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-group study evaluates the safety and potential benefits of high-flow nasal cannula (HFNC) oxygen during fiber-optic bronchoscopy in patients with respiratory failure. HFNC will be started about 10 minutes before the procedure and continued through the bronchoscopy and for 1–2 hours afterward, with oxygen flow adjusted to keep SpO2 near target ranges. The study will monitor oxygenation, ventilation, procedure interruptions, adverse events, patient comfort, and clinical outcomes to determine feasibility and potential improvements over standard care. Patients will receive HFNC via the Vapotherm Precision Flow Hi-VNI system, with FiO2 titrated to maintain SpO2 targets depending on whether they have type 2 respiratory failure. Standard monitoring, including arterial blood gases, will be used to assess safety and response during and after the procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Participants will be eligible for inclusion if they meet all of the following criteria:

1. Adult patients undergoing clinically indicated fiber-optic bronchoscopy.
2. Patients with respiratory failure requiring supplemental oxygen or respiratory support.
3. Patients who provide written informed consent to participate in the study.

Exclusion Criteria:

* Participants will be excluded if they meet any of the following criteria:

  1. Patients requiring immediate endotracheal intubation or invasive mechanical ventilation before bronchoscopy.
  2. Patients with severe or refractory hypoxemia despite maximal non-invasive oxygen/respiratory support before the procedure.
  3. Hemodynamic instability that precludes safe fiber-optic bronchoscopy.
  4. Patients with contraindications to fiber-optic bronchoscopy or to the planned bronchoscopy procedure.
  5. Patients who refuse or withdraw informed consent.
  6. Patients in whom HFNC cannot be safely applied or tolerated.

Where it's running

• Faculty of Medicine, Mansoura University
  Al Mansurah, Dakahlia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Mohammed Shehta, associate professor-chest med.
• Email: dr_mshehta@mans.edu.eg
• Phone: +201004344106

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.