Combination therapy with a helmet-style negative pressure system for acute breathing failure
Official title: Combination Therapy with High-Flow Nasal Cannula and Continuous Negative Extrathoracic Pressure for Acute Hypoxemic Respiratory Failure
Funded at New York University School of Medicine · NIH-11351229 · Data updated 2026-11-12
A new approach tests using high-flow oxygen together with a modern negative pressure device to help adults with acute hypoxemic breathing failure avoid invasive ventilation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 10, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $763,434 |
| NIH project number | 1R61HL186125-01 |
| Project ID | NIH-11351229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with acute hypoxemic respiratory failure eligible for noninvasive support.
✕Less likely to help
Patients not suitable for noninvasive strategies or with contraindications to negative pressure therapy may not benefit.
What this research studies
This grant explores a treatment strategy for adults with acute hypoxemic respiratory failure who often need strong oxygen support. The team will test whether combining high-flow nasal oxygen with negative pressure ventilation can reduce the need for invasive ventilation and improve comfort and breathing. The study builds on the idea that noninvasive support can be enhanced by unloading the chest muscles and aiding lung recruitment, potentially lowering risks and shortening recovery. Results could inform bedside practice and help patients in critical care settings who struggle with breathing.
Why it matters
Potential benefit: If successful, patients with severe breathing failure may need less invasive support and have a better chance of recovery.
How similar studies have gone: Previous noninvasive approaches have reduced intubation in some patients, but combining HFNC with negative pressure ventilation is a novel approach.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Beitler, Jeremy R. — New York University School of Medicine
- Study coordinator: Beitler, Jeremy R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.