Investigating Biomarkers in Acute Respiratory Distress Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients diagnosed with Acute Respiratory Distress Syndrome (ARDS) and aims to explore the expression of SERPINB3 and the polymorphism SCCA-PD, as well as the role of protease-activated receptor 2 (PAR2) in the disease's pathophysiology. By conducting a detailed clinical and biomolecular phenotyping, the study seeks to uncover new insights into the mechanisms of lung injury associated with ARDS. The research will analyze how these biomarkers correlate with the severity of lung injury and inflammation in affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ARDS DIAGNOSIS
* IMV

Exclusion Criteria:

* Age under 18 years
* Pregnancy status
* Lack of consent to participate in the study
* Contraindications to fiberoptic bronchoscopy and/or BAL (bronchoalveolar lavage)
* Patients with chronic inflammatory skin conditions
* Patients with chronic lung diseases
* Patients with inflammatory respiratory diseases
* Patients with neoplasms such as: squamous cell carcinoma of the cervix, squamous cell carcinoma of the esophagus, lung adenocarcinoma, breast adenocarcinoma, pancreatic adenocarcinoma, hepatocellular carcinoma
* History of active or passive smoking

Where it's running

• Azienda Ospedaliera di Padova
  Padova, Pd, Italy Recruiting

Study contacts

• Study coordinator: Annalisa Boscolo, Professor
• Email: annalisa.boscolo@gmail.com
• Phone: +393498324972

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.