Breathing effort and ventilator safety in severe respiratory failure
Official title: Respiratory Drive in Acute Respiratory Failure
Funded at New York University School of Medicine · NIH-11258593 · Data updated 2026-11-12
This research looks at how a person's own breathing effort affects lung and diaphragm injury for adults on ventilators for acute respiratory failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 15, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $822,882 |
| NIH project number | 7R01HL168102-03 |
| Project ID | NIH-11258593 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults admitted to the ICU with acute respiratory failure who require invasive mechanical ventilation and are treated at the enrolling hospital are the intended participants.
✕Less likely to help
People who are not on invasive mechanical ventilation, pediatric patients, or those with chronic stable respiratory conditions outside the ICU would not be eligible or likely to benefit directly from this project.
What this research studies
If you are on a ventilator for acute respiratory failure, the team will measure your own breathing effort, ventilator settings, and lung mechanics to see how the two interact. They will use bedside pressure and flow monitoring, possible imaging and biomarkers, and clinical records to track regional lung stress and signs of diaphragm injury over time. The researchers will compare patterns of high and low respiratory drive and specific patient-ventilator mismatches to see which are linked to worse lung injury or longer need for support. Data will be collected during routine ICU care and tied to outcomes like lung recovery, length of ventilation, and survival.
Why it matters
Potential benefit: If successful, the work could guide ventilator settings that reduce lung and diaphragm injury and help patients recover faster with better outcomes.
How similar studies have gone: Preclinical animal studies and observational patient data indicate that abnormal respiratory drive can worsen lung and diaphragm injury, but strong clinical trial evidence and tested interventions are still limited.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Beitler, Jeremy R. — New York University School of Medicine
- Study coordinator: Beitler, Jeremy R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.