Understanding how care decisions affect outcomes for patients with breathing problems and sepsis
Official title: Identifying patient subgroups and processes of care that cause outcome differences following ICU vs. ward triage among patients with acute respiratory failure and sepsis
Funded at University of Pennsylvania · NIH-11160556 · Data updated 2026-11-12
This project looks at hospital records to understand how decisions about where patients with severe breathing issues and sepsis receive care affect their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $734,655 |
| NIH project number | 5R01HL166269-03 |
| Project ID | NIH-11160556 on NIH RePORTER |
Who could benefit from this research
✓Could help
This project focuses on understanding past care for patients who have experienced acute respiratory failure and sepsis.
✕Less likely to help
Patients who have not experienced acute respiratory failure or sepsis would not directly benefit from this specific research.
What this research studies
We know that where patients with acute respiratory failure and sepsis are treated—either in an intensive care unit (ICU) or a regular hospital ward—can greatly impact their health. This project will analyze a vast amount of patient health record data from many hospitalizations to identify specific groups of patients and care practices that lead to better or worse outcomes. By understanding these differences, we hope to improve how these critical decisions are made. Our goal is to help ensure patients receive the most appropriate care for their condition.
Why it matters
Potential benefit: If successful, this work could lead to more informed decisions about where patients with acute respiratory failure and sepsis receive care, potentially improving their chances of recovery and reducing complications.
How similar studies have gone: Prior work by this team has already shown that initial care decisions significantly impact patient outcomes, suggesting a strong foundation for this expanded analysis.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Anesi, George L — University of Pennsylvania
- Study coordinator: Anesi, George L
Related research
Other NIH-funded projects on the same topics.
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Understanding which patients and hospital care pathways affect outcomes after ICU vs ward care for ARF and sepsis
A big study using hospital records to figure out which patients with acute respiratory failure and sepsis do best when admitted to ICUs versus general wards.
-
Understanding the risks of acute respiratory failure in patients with hospital-onset sepsis
This study looks at how patients with hospital-onset sepsis might face different chances of developing breathing problems, and it aims to find better ways to treat those at higher risk so they can get the care they need to feel better.
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Understanding why critically ill patients with respiratory failure and sepsis face health disparities.
This study is looking into why critically ill patients with breathing problems and infections, especially those from minority backgrounds, often have worse health outcomes, and it aims to find ways to improve their care based on their unique challenges.
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Understanding how ICU and ward care affects patients with severe respiratory issues and sepsis
This study looks at how choosing to treat patients with serious breathing problems and infections in either intensive care units or regular hospital rooms affects their recovery, with the aim of finding ways to improve care for these patients.
-
Using Ganciclovir to Prevent Cytomegalovirus Reactivation in Patients with Severe Respiratory Issues
This study is looking at whether the antiviral medication ganciclovir can help prevent the reactivation of cytomegalovirus (CMV) in adults with severe respiratory failure caused by sepsis, to see if it can improve their recovery and reduce the time they spend on a ventilator and in the ICU.
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Using ganciclovir to stop cytomegalovirus from reactivating in patients with severe respiratory failure and sepsis
This study is looking at whether the antiviral drug ganciclovir can help prevent a virus called cytomegalovirus (CMV) from coming back in adults who are seriously ill with respiratory failure from sepsis, and it’s for people who want to help improve treatment options for patients in critical condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.