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Clinical trial Recruiting at 1 site Observational Ages 18 and up

Platelet population changes during ECMO circulatory support

Official title: Study of Platelet Population Changes Under Circulatory Support With ECMO

Run by University Hospital, Strasbourg, France · NCT07334457 · Data updated 2026-11-12

This will test whether the proportions of different platelet types change during ECMO in adults with cardiac or respiratory failure.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment75 (estimated)
SponsorUniversity Hospital, Strasbourg, France
Academic / other
Locations1 site (Strasbourg)
StatusRecruiting
StartedMarch 11, 2025
Main results expectedMarch 2027
Study endsMarch 11, 2027
Registry record updatedJanuary 12, 2026
Trial IDNCT07334457 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (≥18 years) treated in the ICUs of the Anesthesia and Intensive Care Department at Strasbourg University Hospital who were placed on veno-arterial or veno-venous ECMO within the previous 24 hours and are eligible to participate.

Probably not a fit

Patients who are under legal protection, under guardianship or curatorship, who explicitly object to participation, or those not on ECMO (including pediatric patients) are unlikely to benefit from this study's findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses advanced flow cytometry to profile four major platelet populations (native, proaggregating, procoagulating, and apoptotic) in adults receiving veno-arterial or veno-venous ECMO. Blood samples will be taken shortly after ECMO implantation and analyzed to document shifts in platelet phenotype proportions over time. The study will link these population changes to known hemostatic complications seen during ECMO to identify patterns associated with bleeding or thrombosis. No investigational treatments are given; the protocol focuses on laboratory measurement and clinical correlation.

Why it matters

Potential benefit: If successful, the findings could help predict bleeding or clotting risks and guide anticoagulation or transfusion decisions for patients on ECMO.

How similar studies have gone: Flow cytometry has previously characterized platelet phenotypes in other settings, but applying detailed platelet population profiling specifically during ECMO is relatively novel and remains largely untested.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Adult patient (≥18 years) treated in one of the intensive care units of the Anesthesia and Intensive Care Department at Strasbourg University Hospital.
* Implanted with veno-arterial or veno-venous ECMO within the previous 24 hours.

Exclusion Criteria:

* Subject who has expressed their opposition to participating in the study.
* Subject under legal protection.
* Subject under guardianship or curatorship.

Where it's running

  • Service d'anesthésie-réanimation - CHU de Strasbourg - France
    Strasbourg, France     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Cardiac Failure 16Respiratory Failure 116University Hospital, Strasbourg, France 195
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.