Platelet population changes during ECMO circulatory support
Study of Platelet Population Changes Under Circulatory Support With ECMO
This will test whether the proportions of different platelet types change during ECMO in adults with cardiac or respiratory failure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT07334457 on ClinicalTrials.gov |
What this trial studies
This observational study uses advanced flow cytometry to profile four major platelet populations (native, proaggregating, procoagulating, and apoptotic) in adults receiving veno-arterial or veno-venous ECMO. Blood samples will be taken shortly after ECMO implantation and analyzed to document shifts in platelet phenotype proportions over time. The study will link these population changes to known hemostatic complications seen during ECMO to identify patterns associated with bleeding or thrombosis. No investigational treatments are given; the protocol focuses on laboratory measurement and clinical correlation.
Who should consider this trial
Good fit: Adults (≥18 years) treated in the ICUs of the Anesthesia and Intensive Care Department at Strasbourg University Hospital who were placed on veno-arterial or veno-venous ECMO within the previous 24 hours and are eligible to participate.
Not a fit: Patients who are under legal protection, under guardianship or curatorship, who explicitly object to participation, or those not on ECMO (including pediatric patients) are unlikely to benefit from this study's findings.
Why it matters
Potential benefit: If successful, the findings could help predict bleeding or clotting risks and guide anticoagulation or transfusion decisions for patients on ECMO.
How similar studies have performed: Flow cytometry has previously characterized platelet phenotypes in other settings, but applying detailed platelet population profiling specifically during ECMO is relatively novel and remains largely untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient (≥18 years) treated in one of the intensive care units of the Anesthesia and Intensive Care Department at Strasbourg University Hospital. * Implanted with veno-arterial or veno-venous ECMO within the previous 24 hours. Exclusion Criteria: * Subject who has expressed their opposition to participating in the study. * Subject under legal protection. * Subject under guardianship or curatorship.
Where this trial is running
Strasbourg
- Service d'anesthésie-réanimation - CHU de Strasbourg - France — Strasbourg, France (Recruiting)
Study contacts
- Study coordinator: Charles TACQUARD, MD, PhD
- Email: charlesambroise.tacquard@chru-strasbourg.fr
- Phone: 33.3.69.55.16.08
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.