Using a diaphragm ultrasound index (DPSI) to set high-flow nasal oxygen flow

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study using speckle-tracking ultrasound to derive a Diaphragmatic Physiology Similarity Index (DPSI) and observe its behavior. The study will characterize DPSI features in healthy volunteers and in adults with acute respiratory failure, and will record DPSI changes across different HFNC flow settings during a standardized high-flow adjustment sequence. Secondary work will measure feasibility, inter-operator reproducibility, diaphragmatic contraction synchrony, end-diaphragmatic residual contraction (EDRC), displacement velocity, and maximum displacement. All imaging and flow adjustments are performed at Sir Run Run Shaw Hospital with ICU patients and healthy adult comparators.

Why it matters

Who can join: the full rules

Feasibility and reproducibility：adult ICU patients

Methodology for diaphragmatic motion synchrony:healthy adults and adult ICU patients Between-group comparisons and flow-titration study

Inclusion Criteria:

1. Age ≥18 years old.
2. Clear diagnosis of respiratory failure requiring respiratory support.
3. Expected duration of respiratory support ≥24 hours or (high-flow/non-invasive ventilation) ≥48 hours.
4. Voluntary participation in this study and signed informed consent. If the participant is unable to read or sign the informed consent form due to incapacity (e.g., unconsciousness), the legal guardian must act as a proxy in the informed consent process and sign the form. If the participant cannot read the consent form (e.g., illiterate participants), a witness must observe the informed consent process and sign the form.

Exclusion Criteria:

1. Severe chest wall deformities or diaphragmatic paralysis.
2. End-stage disease with a predicted life expectancy of less than 24 hours.
3. Inability to acquire STE (strains and echoes) images (e.g., severe subcutaneous emphysema, position limitations).
4. Vulnerable groups other than critically ill patients/elderly/illiterate individuals, including those with mental disorders, cognitive impairments, pregnant women, etc.

Where it's running

• Sir Run Run shaw Hospital Zhejiang University
  Hangzhou, Zhejiang, China Recruiting
• Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China Not yet recruiting

Study contacts

• Study coordinator: Huiqing Ge
• Email: gehq@zju.edu.cn
• Phone: +86 13588706787

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.