Understanding how lung immune cells affect COVID-19 lung damage
Novel animal models to dissect how lung macrophages contribute to SARS-CoV2 alveolar pathology and respiratory failure
This study is looking at how certain immune cells might be hurting the lungs of people with severe COVID-19, and it's for anyone interested in understanding more about the virus and finding better ways to help patients breathe easier.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10979157 on NIH RePORTER |
What this research studies
This research investigates the role of macrophages, a type of immune cell, in causing lung damage related to COVID-19. By using both human and mouse models, the researchers aim to develop new mouse models that can help identify how SARS-CoV2 affects lung cells. The study involves collaboration among experts in various fields, including lung biology and virology, to gain insights into the mechanisms of respiratory failure caused by the virus. The findings could lead to better understanding and treatment options for patients suffering from severe COVID-19 symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe respiratory issues or lung damage due to COVID-19.
Not a fit: Patients who have not been infected with SARS-CoV2 or who do not exhibit respiratory complications from COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lung damage caused by COVID-19.
How similar studies have performed: Other research has shown promise in understanding immune responses to viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Gludish, David W — Cornell University
- Study coordinator: Gludish, David W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.