Low-flow ECCO2R for ICU patients with respiratory failure: safety and outcomes
Official title: Retrospective Cohort Study of Low-Flow Extracorporeal Carbon Dioxide Removal (ECCO2R) System: Evaluating Efficacy and Safety
Run by Hong Kong University · NCT07161271 · Data updated 2026-11-12
This review looks back at adults in the ICU who received low-flow ECCO2R to see if the treatment was safe and helped people with respiratory failure, including ARDS and severe asthma.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 59 (estimated) |
| Sponsor | Hong Kong University Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | November 1, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | December 23, 2025 |
| Trial ID | NCT07161271 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18 years or older) who were admitted to the ICU at Queen Mary Hospital and received low-flow ECCO2R between January 1, 2022 and June 30, 2024 are the subjects of this review.
✕Probably not a fit
Patients who were not treated with ECCO2R, treated at other hospitals, or under 18 years old would not be represented and so would not directly benefit from the study's conclusions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective chart review of adult patients treated with low-flow extracorporeal carbon dioxide removal (ECCO2R) at Queen Mary Hospital between January 1, 2022 and June 30, 2024. The team will describe which patients were selected for ECCO2R, specific technical and clinical management choices, and short-term clinical outcomes and adverse events. Data will be drawn from routinely collected ICU records to characterize practice patterns and complications associated with low-flow systems. The goal is to identify factors that could improve the quality and safety of ECCO2R use in critically ill patients.
Why it matters
Potential benefit: If findings show favorable safety and outcomes, clinicians could better select patients and manage low-flow ECCO2R to reduce complications and improve ICU care.
How similar studies have gone: Previous small trials of ECCO2R have produced physiological benefits such as reduced ventilator intensity but have not consistently shown improved mortality, and low-flow systems remain less well studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients supported with ECCO2R in one of the designated study sites * Admitted to the ICU between 1 Jan 2022 and 30 June 2024 Exclusion Criteria: * Patients younger than 18 years old
Where it's running
-
Queen Mary Hospital (QMH)
Hong Kong, Hong Kong Recruiting
Study contacts
- Study coordinator: Wai Ching Simon Sin, Director, Clinical Professor
- Email: drwcsin@hku.hk
- Phone: (852)9090-8772
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.