High-flow oxygen treatment after spinal cord injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized feasibility trial will assign adults with acute cervical or upper thoracic spinal cord injury (C4–T4) to receive either standard care or high-flow oxygen therapy for 10 days after enrollment. The primary goals are to determine if patients can be recruited, if the protocol can be followed as written, and to collect preliminary data on the intervention's effects on respiratory outcomes. Key inclusion criteria include admission to the spinal injury ward within 24–48 hours of injury and ASIA grades A–D, while major chest trauma, concomitant lung injury, undrained pneumothorax, or facial/skull-base injuries are excluded. The single-site study is run by Cardiff and Vale University Health Board in Cardiff, UK.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Spinal cord injury between C4 and T4 (Include ASIA A-D)
2. Admitted to spinal injury ward within 24-48hours of injury

Exclusion Criteria:

1. Aged under 18 years
2. 3 or more rib fractures or flail
3. Sternal fracture
4. Concomitant lung injury
5. Unable to gain informed consent from participant
6. Contra-indication to using high flow therapy e.g., undrained pneumothorax, facial fractures, nasal obstruction, CSF leak, suspected or confirmed base of skull fracture, active epistaxis or recent functional endoscopic sinus surgery.

Where it's running

• Cardiff and Vale University Health Board
  Cardiff, United Kingdom Recruiting

Study contacts

• Principal investigator: Paul Twose — Cardiff and Vale University Health Board
• Study coordinator: Paul Twose, MSc
• Email: paul.twose@wales.nhs.uk
• Phone: 07739315830

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.