Evaluating lung function in children after severe respiratory illness
Official title: Use of Oscillometry for the Evaluation of Pulmonary Function Following Pediatric Acute Respiratory Failure.
Funded at Seattle Children's Hospital · NIH-11117616 · Data updated 2026-11-12
This study is looking at how to check lung health in young kids under 6 who have recovered from serious breathing problems, like those caused by pneumonia or asthma, using a gentle method that doesn't require them to do any tricky breathing exercises, so we can better understand how these issues affect their lungs in the long run.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $224,083 |
| NIH project number | 1R21HD118297-01 |
| Project ID | NIH-11117616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 6 years old who have experienced acute respiratory failure.
✕Less likely to help
Patients who are older than 6 years or do not have a history of acute respiratory failure may not benefit from this research.
What this research studies
This research investigates how to assess lung function in children under 6 years old who have survived acute respiratory failure, a serious condition often caused by pneumonia or asthma. The study will utilize oscillometry, a non-invasive technique that measures lung function without requiring children to perform complex breathing maneuvers. By focusing on this younger population, the research aims to fill a critical gap in understanding the long-term effects of acute lung injury on their pulmonary health. The findings could lead to better monitoring and treatment strategies for these vulnerable patients.
Why it matters
Potential benefit: If successful, this research could provide a reliable method for assessing lung function in young children, leading to improved care and outcomes for those recovering from acute respiratory failure.
How similar studies have gone: While there have been studies on lung function in older children, the use of oscillometry in very young children with acute respiratory failure is a novel approach.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Killien, Elizabeth Y — Seattle Children's Hospital
- Study coordinator: Killien, Elizabeth Y
Related research
Other NIH-funded projects on the same topics.
-
Using a simple breathing test to check lung function after kids’ acute respiratory failure
A study will test a child-friendly breathing method (oscillometry) to check how well lungs work after severe respiratory illness in kids.
-
Financial hardship in acute respiratory failure patients and their family caregivers
This grant studies how money worries affect patients with acute respiratory failure and their family caregivers, aiming to improve outcomes for both sides.
-
Understanding which patients and hospital care pathways affect outcomes after ICU vs ward care for ARF and sepsis
A big study using hospital records to figure out which patients with acute respiratory failure and sepsis do best when admitted to ICUs versus general wards.
-
Optimizing Time-Limited Trials of Ventilation in Acute Respiration Failure
Aimed at patients with acute respiratory failure, this project looks at how short-term trials of life-support in the ICU can be better planned and communicated.
-
Using a simple breathing test to check how kids recover lung function after severe lung illness
A study will test a quick, noninvasive breathing test called oscillometry to see how well children who survived dangerous lung problems recover over time.
-
Breathing effort and ventilator safety in severe respiratory failure
This research looks at how a person's own breathing effort affects lung and diaphragm injury for adults on ventilators for acute respiratory failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.