Using noradrenaline to prevent cardiovascular collapse during tracheal intubation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The PREVENTION trial aims to evaluate the effectiveness of pre-emptive noradrenaline administration in preventing cardiovascular collapse during tracheal intubation in critically ill adults. This multi-center, randomized study will compare outcomes between patients receiving a continuous infusion of noradrenaline before intubation and those receiving no vasopressors. The primary outcome will focus on the incidence of cardiovascular collapse, while secondary outcomes will assess blood pressure changes and cardiac arrest rates within 30 minutes post-intubation. Eligible participants include adults requiring intubation due to critical illness, with specific exclusion criteria for those with contraindications to vasopressors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient is admitted or scheduled for admission to a participating study hospital
* Planned procedure is tracheal intubation and planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit
* Critical illness (i.e. life-threatening condition with intubation required for cardiorespiratory failure or neurological impairment)
* Administration of sedation (with or without neuromuscular blockade) is planned
* Age 18 years or older

Exclusion Criteria:

* No vasopressors/inotropes at the moment of screening for eligibility
* MAP \< 60 mmHg or \> 120 mmHg at the moment of screening for eligibility
* Urgency of intubation precludes safe performance of study procedures
* Intubation performed during cardiopulmonary resuscitation of a patient in cardiac arrest
* Enrolled in another clinical trial that is unapproved for co-enrollment
* Pregnant or suspected pregnancy

Where it's running

• Humanitas Research Hospital
  Rozzano, Milan, Italy Recruiting
• ASST Grande Ospedale Metropolitano Niguarda
  Milan, Italy Recruiting
• Policlinico di Milano
  Milan, Italy Recruiting
• CHU de Nantes
  Nantes, France Not yet recruiting
• Galway University Hospitals
  Galway, Ireland Not yet recruiting
• University Hospital San Luigi Gonzaga
  Orbassano, Turin, Italy Not yet recruiting

Study contacts

• Principal investigator: Vincenzo Russotto, MD — University Hospital San Luigi Gonzaga
• Study coordinator: Vincenzo Russotto, MD
• Email: vincenzo.russotto@unito.it
• Phone: +393297893044

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.