Identifying biomarkers to predict respiratory failure after blood cell transplants
Official title: Prognostic biomarkers for respiratory failure post hematopoietic cell transplantation
Funded at Indiana University Indianapolis · NIH-10915039 · Data updated 2026-11-12
This study is looking at certain markers in the blood to see if they can help doctors predict which patients who have had a stem cell transplant might be at risk for breathing problems, so they can take action before any serious issues arise.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $180,385 |
| NIH project number | 5K23HL150244-05 |
| Project ID | NIH-10915039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals undergoing hematopoietic cell transplantation, particularly those with a history of respiratory issues or other risk factors.
✕Less likely to help
Patients who are not undergoing hematopoietic cell transplantation or those with stable respiratory conditions may not benefit from this research.
What this research studies
This research investigates how specific biomarkers can predict the risk of respiratory failure in patients who have undergone hematopoietic cell transplantation (HCT). By measuring these biomarkers at various time points after the transplant, the study aims to identify patients at higher risk for respiratory complications before symptoms appear. The approach includes both proteomic discovery and validation of biomarkers, which could lead to early interventions to prevent respiratory failure. The research involves a multicenter study to establish thresholds for these biomarkers, enhancing patient care.
Why it matters
Potential benefit: If successful, this research could enable earlier interventions for patients at risk of respiratory failure, potentially improving their outcomes after transplantation.
How similar studies have gone: Previous research has shown promise in using biomarkers for predicting complications in transplant patients, suggesting that this approach could be effective.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Rowan, Courtney — Indiana University Indianapolis
- Study coordinator: Rowan, Courtney
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.