Monitoring lung changes from prone positioning in ARDS with 3D electrical impedance tomography
Prone Position Assessment by 3D EIT in ARDS Patients
Peking Union Medical College Hospital · NCT07083973
This will see if turning adults on ventilators with ARDS onto their stomachs changes lung air distribution and blood flow as measured by 3D electrical impedance tomography, and it will compare 3D to 2D EIT for monitoring.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Peking Union Medical College Hospital (other) |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT07083973 on ClinicalTrials.gov |
What this trial studies
This observational study will record global and regional lung ventilation and perfusion changes when mechanically ventilated ARDS patients are placed in the prone position using 3D electrical impedance tomography (3D-EIT). Patients who are clinically judged to need prone positioning will be monitored before, during, and after proning without changing standard care. The study will directly compare measurements from conventional 2D-EIT with those from 3D-EIT to identify differences in monitoring performance. The work is conducted at the Department of Critical Care Medicine, Peking Union Medical College Hospital in Beijing and excludes patients with implanted devices, ribcage malformations, pregnancy, or age under 18.
Who should consider this trial
Good fit: Ideal candidates are adult patients with ARDS on mechanical ventilation who require prone positioning and have no contraindications to EIT (for example, no implantable cardiac devices, pumps, ribcage malformations, or pregnancy).
Not a fit: Patients not on mechanical ventilation, those with contraindications to EIT, pregnant patients, or those with chest wall deformities or implanted devices are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this could help clinicians better tailor prone positioning and monitor regional lung function noninvasively, potentially improving oxygenation and reducing ventilator-related injury.
How similar studies have performed: Prone positioning has been shown in prior trials to improve outcomes in moderate–severe ARDS, while electrical impedance tomography has been used for bedside monitoring and 3D-EIT is a newer, less-tested extension compared with established 2D-EIT.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients on mechanical ventilation. * Diagnosis of ARDS was based on the Berlin definition * Patients in need of prone position because of clinical condition Exclusion Criteria: * Under 18 years of age. * Pregnant women; * Ribcage malformation * Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).
Where this trial is running
Beijing, Beijing Municipality
- Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences — Beijing, Beijing Municipality, China (RECRUITING)
Study contacts
- Study coordinator: Huaiwu He
- Email: tjmuhhw@163.com
- Phone: 01069152301
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: ARDS, Respiratory Failure