Clinical trial Recruiting at 1 site Observational Ages 18 and up

Understanding quality of life in patients with chronic respiratory failure

Official title: Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure

Run by Guy's and St Thomas' NHS Foundation Trust · NCT04236726 · Data updated 2026-11-12

This study looks at how different treatments for chronic respiratory failure, like non-invasive ventilation, affect the daily lives and well-being of patients.

More Chronic Obstructive Pulmonary Disease trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorGuy's and St Thomas' NHS Foundation Trust
Academic / other
Locations1 site (London)
StatusRecruiting
StartedDecember 19, 2019
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJune 4, 2026
Trial IDNCT04236726 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults diagnosed with chronic respiratory failure who are currently receiving specific respiratory interventions.

Probably not a fit

Patients under 18 years old or those with significant co-morbidities that hinder compliance with the study protocol may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the quality of life in patients suffering from chronic respiratory failure, including those with chronic obstructive pulmonary disease and neuromuscular diseases. It will utilize questionnaires to gather data on how various interventions impact the patients' daily lives and overall well-being. The study focuses on patients who are receiving treatments such as non-invasive ventilation and prolonged mechanical ventilation. By analyzing this data, the study seeks to provide insights into the effectiveness of current interventions on quality of life.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies that enhance the quality of life for patients with chronic respiratory failure.

How similar studies have gone: While this approach is observational and may not have been extensively tested in this specific context, similar studies have shown that understanding quality of life can lead to better patient outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Diagnosed with chronic respiratory failure receiving any of:

* Non-invasive ventilation
* Prolonged mechanical ventilation
* Mechanical insufflation-exsufflation therapy

Exclusion Criteria:

* Aged \<18
* Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol

Where it's running

  • Guy's and St. Thomas NHS Foundation Trust
    London, United Kingdom
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.