High-flow oxygen therapy for patients weaning off mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of high-flow tracheal oxygen (HFTO) on airway mucus viscosity and respiratory effort in patients with tracheostomies who are transitioning off invasive mechanical ventilation. The research aims to determine if HFTO can reduce sputum thickness and improve respiratory support during the weaning process compared to conventional oxygen therapy. By focusing on these physiological parameters, the study seeks to enhance patient outcomes during a critical phase of recovery from respiratory failure.

Why it matters

Who can join: the full rules

Inclusion:

* Age ≥18 years
* Weaning from mechanical ventilation with tracheostomy

Exclusion Criteria:

* Longstanding tracheostomy, defined as tracheostomy being present prior to current hospital admission
* Tracheostomy primarily indicated for chronic upper airway obstruction or to secure airway patency due to persistent stupor/coma
* Chronic positive pressure respiratory support at home (excluding night-time continuous positive airway pressure for sleep apnea)
* Mucociliary disease in medical history (e.g. cystic fibrosis, pulmonary ciliary dyskinesia)
* Neuromuscular disease in medical history (excluding ICU-acquired weakness)
* Contra-indication placement oesophageal balloon for measurement of PES, such as:

  * Fractures in mandibular, orbital or ethmoid bone or skull base
  * Esophageal varices or surgery in medical history
  * Severe bleeding disorders
* Hemoptysis in 72 hours prior to the first disconnection session. Clinically relevant hemoptysis is defined as hemoptysis requiring tracheal/endobronchial or radiologic intervention, or administration of pro-coagulating drugs such as tranexamic acid.

Where it's running

• Erasmus Medical Center
  Rotterdam, Netherlands Recruiting

Study contacts

• Study coordinator: Thijs Janssen Resident pulmonology, Critical Care researcher, MD
• Email: m.l.janssen@erasmusmc.nl
• Phone: 0107035142

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.