Condition

Pneumonia clinical trials and research

• 72Clinical trials
• 150NIH research projects
• 3New in 30 days
• 46Countries

Newest Pneumonia clinical trials

All recruiting trials (72)

• Respiratory Physiotherapy in Critically Ill Pneumonia Patients

  This study tests whether a structured breathing and chest therapy program can change inflammatory biomarkers in adults with pneumonia in the ICU compared to usual care.

  Recruiting Hospital H+ Queretaro · Querétaro · NCT07909616

• AI-powered CT help to guide pneumonia care

  A multicenter trial tests whether using a chest CT–based AI report to guide care reduces death or need for new organ support in adults with pneumonia.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07895290

• Wintergreen oil inhalation for shortness of breath in pneumonia patients

  Hospitals will test whether inhaling wintergreen essential oil helps relieve dyspnea in adults with pneumonia.

  Recruiting Far Eastern Memorial Hospital · New Taipei City, Taipei · NCT07894835

• Optimising Antibiotic Use for Paediatric LRTIs in Africa

  This study tests whether using point-of-care CRP tests together with the PREPARE score can safely reduce antibiotic use in infants aged 2–24 months with lower respiratory infections in a Johannesburg hospital.

  Recruiting University of Witwatersrand, South Africa · Johannesburg, Gauteng · NCT07841691

• Buteyko Breathing vs Incentive Spirometry for Smog-Induced Pneumonia

  We’re testing whether the Buteyko Breathing Technique can improve oxygen levels and breathe easier for adults with smog-related pneumonia compared to incentive spirometry.

  Recruiting Lahore University of Biological and Applied Sciences · Lahore, Punjab Province · NCT07759583

• FUNGAL-P: A score to spot fungal pneumonia early in adults with pneumonia

  Aimed at adults with pneumonia, this study tests a new score to help identify fungal pneumonia sooner so doctors can test appropriately and start antifungal treatment when needed.

  Recruiting Azienda Ospedaliero-Universitaria Careggi · Florence · NCT07681583

• AgenT-797 plus standard care in severe pneumonia with acute hypoxemic respiratory failure

  We are testing whether a single IV dose of agenT-797 added to standard care can reduce short-term death in adults with severe pneumonia and moderate to severe AHRF.

  Recruiting Phase 2 MiNK Therapeutics · San Francisco, California and 3 other locations · NCT07615010

• Biomarker patterns in ACS patients with pneumonia and COPD after flu vaccination

  This study tests whether certain blood biomarkers change in people with acute coronary syndrome who also have pneumonia and COPD, and whether flu vaccination affects those biomarker levels.

  Recruiting Phase 3 University of Brawijaya · Malang, East Java · NCT07604103

• Sulbactam-Durlobactam for CRAB infections in real-world care

  This real-world study tests whether sulbactam-durlobactam works and is safe for adults with carbapenem-resistant Acinetobacter baumannii infections, compared with other anti-CRAB treatments.

  Recruiting Sichuan Provincial People's Hospital · Chengdu, Sichuan · NCT07601711

• Low-intensity laser therapy to boost immune response in children with pneumonia

  This trial will test whether adding low-intensity laser therapy to breathing exercises and usual medical care helps immune markers and breathing in children with Down syndrome and pneumonia.

  Recruiting Badr University · Cairo · NCT07552116

• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

• Comparing Acute Medical Unit care versus usual ward care for adults with sudden medical illnesses

  This research will see if care in an Acute Medical Unit (AMU) leads to better outcomes than usual general-ward care for adults admitted from the emergency department with infections, falls, or COPD flare-ups.

  Recruiting National University Hospital, Singapore · Singapore · NCT07536035

• Proactive pharmacist e-consults to optimize lung health for people with HIV

  This trial tests whether proactive pharmacist-led e-consults can help people with HIV improve lung-health medications, vaccinations, smoking cessation, and deprescribing of certain inhaled medicines or PPIs.

  Recruiting Seattle Institute for Biomedical and Clinical Research · Boise, Idaho and 2 other locations · NCT07507435

• Pneumonia Care Helper: using a chatbot to support family caregivers at home

  A chatbot-based digital education tool is tested to see if it helps family caregivers of elderly pneumonia patients learn better care skills than traditional paper instructions.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei, Taiwan · NCT07463443

• Intrapulmonary percussion ventilation added to breathing support for adults with pneumonia on a ventilator

  This trial will test whether adding intrapulmonary percussion ventilation (IPV) to usual airway clearance shortens time on a ventilator and improves lung ventilation in adults with pneumonia who are invasively mechanically ventilated.

  Recruiting Zhongnan Hospital · Wuhan, Hubei · NCT07453966

• Safety and performance of the INBENTUS VERSATILE ventilator in adults on invasive mechanical ventilation

  This trial will test whether the INBENTUS VERSATILE ventilator is safe and performs well in adults who need assisted or controlled invasive mechanical ventilation and short-term weaning.

  Recruiting Iconic Solutions By Murcia SL · Murcia · NCT07432191

• Measuring airway inflammation markers in breath to help detect lung conditions

  This project tests whether a breath test called Inflammacheck® that measures hydrogen peroxide and other inflammation markers can quickly triage adults with suspected or confirmed lung cancer and other respiratory conditions.

  Recruiting Portsmouth Hospitals NHS Trust · Portsmouth, Hampshire · NCT07426718

• OLE airway clearance with EIT monitoring for ICU patients with pneumonia

  This tests whether Oscillatory Lung Expansion (OLE) airway clearance, monitored with electrical impedance tomography (EIT), helps adult ICU patients with pulmonary infections clear secretions and improve cough strength.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07395297

• Preventing pneumonia after brain hemorrhage with extra mouth care and preventive antibiotics

  This will test whether enhanced oral hygiene combined with preventive antibiotics can help adults who recently had a spontaneous intracerebral hemorrhage avoid pneumonia.

  Recruiting Phase 4 Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07311343

• Using higher PEEP with mask noninvasive ventilation for people with pneumonia or ARDS

  This trial will test whether giving higher PEEP through a mask during noninvasive ventilation helps adults with pneumonia or ARDS avoid intubation and improve oxygenation.

  Recruiting Chongqing Medical University · Chongqing · NCT07298889

• Impact of Low vs High PEEP on Diaphragm and Lung Function in Mechanically Ventilated Patients

  This study tests whether different levels of PEEP (low, medium, high) change diaphragm effort and ventilation effectiveness in adults on pressure-support ventilation in the ICU.

  Recruiting Vastra Gotaland Region · Gothenburg, Västra Götaland County and 1 other locations · NCT07188038

• Urine Pneumococcal Antigen Test in Children with Pneumonia

  This study tests a non-invasive urine test to see if it can detect pneumococcal pneumonia and identify serotypes in children under five in Malawi.

  Recruiting Liverpool School of Tropical Medicine · Blantyre · NCT07181200

• Improving treatment for children with community-acquired pneumonia in emergency rooms

  This project tests a new care pathway to see if emergency departments can safely give fewer antibiotics to children aged 6 months–18 years with non-severe community-acquired pneumonia who are sent home.

  Recruiting at 2 sites McMaster University · Calgary, Alberta and 5 other locations · NCT07099976

• Using the Lung Sliding Index to distinguish common lung diseases

  This project will test whether the Lung Sliding Index (LSI) measured by bedside ultrasound can tell apart various lung conditions in adults with lung disease and in healthy volunteers.

  Recruiting Assiut University · Asyut · NCT06983366

• Infusion regimen of piperacillin-tazobactam for pneumonia in older adults

  This study tests which way of giving an antibiotic for pneumonia works better for older adults, either every 6 hours or every 8 hours, to help them recover more effectively.

  Recruiting Shandong University · Jinan, Shandong · NCT06972537

• High-dose inhaled nitric oxide for adults with severe pneumonia on ventilators

  This study will test whether short courses of high-dose inhaled nitric oxide help adults on ventilators with severe pneumonia recover and how the treatment affects methemoglobin levels.

  Recruiting Early Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT06950294

• Lung ultrasound to guide antibiotic decisions in children with pneumonia

  This will see if using lung ultrasound for children aged 3–10 with suspected pneumonia leads to fewer antibiotic prescriptions than usual care.

  Recruiting at 7 sites Meyer Children's Hospital IRCCS · San Diego, California and 17 other locations · NCT06921993

• Improving dental care for nursing home residents to reduce infections and enhance diabetes control

  This study tests if better dental care for nursing home residents can help reduce infections and improve diabetes control.

  Recruiting Missouri Department of Health and Senior Services · Jefferson City, Missouri · NCT06890676

• Rib mobilization to help ventilated pneumonia patients breathe on their own

  This trial will try rib mobilization versus routine chest physiotherapy to see if it helps adults with pneumonia come off mechanical ventilators sooner.

  Recruiting Cairo University · Cairo · NCT06835842

• Reducing unnecessary antibiotic use in children with respiratory infections

  This study is testing whether using a new support system in hospitals can help reduce unnecessary antibiotic prescriptions for kids with respiratory infections like pneumonia and bronchiolitis.

  Recruiting Vanderbilt University Medical Center · Oakland, California and 2 other locations · NCT06788093

• Effects of suctioning on pain and stress in intubated ICU patients

  This study is testing if suctioning the breathing tube in ICU patients causes more pain and stress compared to not suctioning.

  Recruiting Loma Linda University · Loma Linda, California · NCT06692400

• Improving treatment of pneumonia in children using lung ultrasound

  This study is testing if using lung ultrasound can help doctors treat pneumonia in kids better and reduce the need for unnecessary antibiotics.

  Recruiting at 8 sites Ecole Polytechnique Fédérale de Lausanne · Dakar, Dakar and 8 other locations · NCT06670833

• Using diaphragmatic ultrasound to diagnose acute respiratory distress in emergency patients

  This study is testing if using diaphragmatic ultrasound can help doctors quickly diagnose pneumonia and other breathing problems in emergency patients who are having trouble breathing.

  Recruiting University Hospital, Montpellier · Nîmes, Gard and 1 other locations · NCT06650137

• Monitoring blood flow and response to fluids in patients on ECMO

  This study is testing different ways to monitor blood flow and heart function in adults receiving VA ECMO treatment to see which methods work best for their care.

  Recruiting Medical University of Vienna · Vienna · NCT06593756

• Testing monitoring methods for patients on ECMO support

  This study is testing different ways to monitor heart function and fluid levels in patients on ECMO support for severe breathing problems to see which methods work best.

  Recruiting Medical University of Vienna · Vienna · NCT06593717

• Monitoring antimicrobial resistance in pneumonia patients using metagenomics

  This study is trying to understand how different germs and their resistance to antibiotics affect patients with mild and severe pneumonia to improve diagnosis and treatment.

  Recruiting Shanghai General Hospital, China · Shanghai, Shanghai Municipality · NCT06566898

• Using portable dynamic chest X-ray in the ICU

  This study is testing a new portable chest X-ray system in the ICU to see if it can give better pictures of lung movement and function compared to regular X-rays and CT scans for critically ill patients.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06538376

• Understanding risk factors and biomarkers in ARDS, sepsis, and pneumonia

  This study is trying to find out what causes acute respiratory distress syndrome, sepsis, and pneumonia by collecting health information and samples from hospitalized adults to help improve treatment for these conditions.

  Recruiting at 20 sites Vanderbilt University Medical Center · Fresno, California and 19 other locations · NCT06521502

• Benefits of Osteopathic Manual Therapy for Patients with Respiratory Illness

  This study is testing if adding Osteopathic Manual Therapy to standard care can help older patients with respiratory illnesses like pneumonia and bronchitis feel better faster.

  Recruiting Geisinger Clinic · Bloomsburg, Pennsylvania · NCT06495021

• Validation of hematological indices in cardiac surgery patients

  This study is testing if certain blood test results can help predict infections and organ problems in patients who are having heart surgery.

  Recruiting Petrovsky National Research Centre of Surgery · Moscow · NCT06476171

• Comparing two types of filters for treating kidney injury in pneumonia patients

  This study is testing which of two filters, Oxiris or M100, works better and is safer for treating kidney injury in patients with pneumonia.

  Recruiting Universiti Sains Malaysia · Kubang Kerian, Kelantan · NCT06440759

• Evaluation of ultra low dose CT scans with Iomeron 400 contrast

  This study is testing if using ultra low dose CT scans with a special contrast dye can help find lung problems like blood clots, cancer, and pneumonia while keeping radiation exposure low.

  Recruiting University of Zurich · Zurich · NCT06360627

• Using Xanthohumol to help treat septic shock

  This study is testing if a natural compound called Xanthohumol can help improve recovery for patients with septic shock who need breathing support.

  Recruiting Phase 2 Medical University of Lublin · Lublin, Lublin Voivodeship · NCT06225258

• Observing symptoms in children with first-onset bronchial asthma

  This study looks at how asthma shows up in kids and teens aged 3 to 18, especially if they have unusual symptoms like a chronic cough, to see if a specific questionnaire can help spot these cases better.

  Recruiting Charles University, Czech Republic · Prague · NCT06201494

• Evaluating medical oxygen access and policies

  This study looks at how access to medical oxygen works in six countries to see what challenges people face and how to improve it for patients and healthcare providers.

  Recruiting at 6 sites Murdoch Childrens Research Institute · Phnom Penh and 5 other locations · NCT06169514

• Using advanced sequencing to guide infection treatment in AIDS patients

  This study is testing if a new DNA sequencing method can help doctors choose better infection treatments for AIDS patients with severe pneumonia or sepsis compared to standard methods.

  Recruiting Guangzhou 8th People's Hospital · Guangzhou, Guangdong · NCT06145841

• Identifying lung function risks in AIDS patients recovering from severe pneumonia

  This study looks at what might affect lung health in people with AIDS who have recovered from severe pneumonia to see how their lungs are doing after they leave the hospital.

  Recruiting Guangzhou 8th People's Hospital · Guangzhou, Guangdong · NCT06137196

• Effect of rTMS on pneumonia in stroke patients with swallowing difficulties

  This study tests if adding a special brain treatment to regular therapy can help stroke patients with swallowing problems avoid pneumonia.

  Recruiting Cairo University · Giza, Giza Governorate · NCT06123650

• New diagnostic methods for pneumonia in older adults

  This study is testing new ways to diagnose pneumonia in older adults in the emergency room to see if they can improve accuracy in identifying different types of infections.

  Recruiting Ohio State University · Columbus, Ohio · NCT06092008

• Evaluation of a multi-country medical oxygen program

  This study is trying to see how medical oxygen is used in hospitals across nine countries to find ways to make it easier for patients, especially children with low oxygen levels, to get the help they need.

  Recruiting Murdoch Childrens Research Institute · Phnom Penh and 2 other locations · NCT06087315

• Using diaphragm ultrasound to predict respiratory complications after surgery

  This study is testing if using ultrasound to check diaphragm function can help predict breathing problems after major surgeries.

  Recruiting at 2 sites Karolinska University Hospital · Stockholm, Stockholm County and 1 other locations · NCT05906030

• Understanding pneumonia progression in hospitalized patients with severe preexisting conditions

  This study is tracking how pneumonia affects hospitalized patients with serious health issues to see if certain signs can help predict their recovery and improve their care.

  Recruiting at 9 sites Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps · Berlin and 9 other locations · NCT05688774

• Observing oxygenation practices during fiberoptic bronchoscopy

  This study looks at how doctors provide oxygen and breathing support to adults during fiberoptic bronchoscopy to better understand current practices.

  Recruiting University Magna Graecia · Catanzaro · NCT05681962

• Using ECMO to help patients with severe respiratory failure recover

  This study is testing if using a special breathing machine called ECMO along with regular ventilation can help patients with severe breathing problems recover faster and spend less time in intensive care.

  Recruiting at 6 sites Australian and New Zealand Intensive Care Research Centre · Darlinghurst, New South Wales and 6 other locations · NCT05562505

• Comparing automatic vs. as-needed follow-up care for children after hospitalization

  This study tests whether regular follow-up visits for kids after being in the hospital can help them stay healthy and avoid going back to the hospital, compared to only seeing a doctor when needed.

  Recruiting at 13 sites University of Utah · Phoenix, Arizona and 13 other locations · NCT05471908

• Learning how the 20-valent pneumococcal vaccine works against pneumonia

  This study is trying to see if the 20-valent pneumococcal vaccine can help prevent pneumonia in people aged 65 and older who are hospitalized with suspected pneumonia.

  Recruiting at 53 sites Pfizer · El Centro, California and 53 other locations · NCT05452941

• Hospital treatment at home for elderly patients with acute illnesses

  This study is testing a new way to treat elderly patients with certain acute illnesses at home instead of in the hospital to see if it keeps them safer and happier.

  Recruiting at 3 sites Defactum, Central Denmark Region · Silkeborg and 2 other locations · NCT05360914

• Emergency PanorOmics Wide Association for Respiratory Infections

  This study is trying to quickly identify different respiratory infections in adults visiting the emergency room to help develop better tests and treatments for these illnesses.

  Recruiting The University of Hong Kong · Hong Kong · NCT05336851

• Observing pneumonia and pleural effusion in hospitalized children

  This study looks at how common pneumonia and fluid around the lungs are in hospitalized children to understand the causes, symptoms, and how well treatments work.

  Recruiting Association Clinique Thérapeutique Infantile du val de Marne · Créteil · NCT05274607

• Hospitalized adults with acute or chronic respiratory conditions: outcomes and recovery

  This study tests how adults hospitalized with acute respiratory problems or chronic lung disease recover after discharge, and what factors predict readmission, stay length, and mortality.

  Recruiting University of Leicester · Leicester · NCT05095090

• Imaging lung function in patients who received stem cell transplants

  This study is testing a special type of MRI to see how well the lungs are working in adults who have had a stem cell transplant and are having breathing problems.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05041140

• A large biobank for acute and emergency medicine

  This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.

  Recruiting University Medical Center Groningen · Groningen · NCT04615065

• Surveillance network for pediatric infectious diseases

  This study is trying to see if training pediatricians to use new testing tools and shared records can help them diagnose and treat infectious diseases in children better.

  Recruiting Association Clinique Thérapeutique Infantile du val de Marne · Créteil · NCT04471493

• Evaluation of treatments to prevent death in hospitalized COVID-19 patients

  This study tests different treatments to see if they can help hospitalized COVID-19 patients with pneumonia live longer and feel better.

  Recruiting at 15 sites Phase 3 University of Oxford · Brussels and 15 other locations · NCT04381936

• Understanding how drugs work in children

  This study is trying to find the best and safest doses of certain medications for children and young adults under 21 who are being treated for conditions like COVID-19 and pulmonary arterial hypertension.

  Recruiting at 5 sites Duke University · Phoenix, Arizona and 51 other locations · NCT04278404

• Improving respiratory care for patients having high-risk abdominal surgery

  This study is testing whether using a special mouthwash and different amounts of oxygen before surgery can help reduce the chances of pneumonia and infections in patients having major abdominal surgery.

  Recruiting at 34 sites Phase 3 University of Birmingham · Botucatu, São Paulo and 36 other locations · NCT04256798

• Using blue light to improve immune response in patients with infections

  This study is testing if bright blue light can help boost the immune response and improve recovery for patients with infections like pneumonia while they are in the hospital.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT03482245

• Examining Monocyte Profiles in Critically Ill Patients with Pseudomonas Aeruginosa Sepsis

  This study is trying to see if the type of immune cells in the blood of critically ill patients with sepsis from Pseudomonas aeruginosa can tell us more about how sick they are and how they might recover.

  Recruiting University of Ulm · Ulm · NCT03044223

• Observational study of pneumonia patients in intensive care

  This study looks at patients with severe pneumonia in the intensive care unit to see how the illness affects them and what factors might influence their recovery.

  Recruiting Beijing Chao Yang Hospital · Beijing, Beijing Municipality · NCT02738645

• Pneumococcal infection surveillance in Lebanon

  This study is trying to find out which types of bacteria cause serious infections like pneumonia in Lebanon and how well current vaccines and antibiotics work against them.

  Recruiting American University of Beirut Medical Center · Beirut · NCT00901602

• Examining Lung Proteins in Patients with Pneumonia

  This study is testing lung fluid samples from pneumonia patients to see if certain proteins can help identify the causes of their lung issues and improve treatment options.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00077909

• Understanding Hyper IgE Recurrent Infection Syndrome

  This study is looking for patients and families with Hyper IgE Syndrome to see how their symptoms are linked to genetic changes and to learn more about managing the condition over time.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00006150

NIH-funded research (newest 40 of 150)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Coordinating ARDS, Pneumonia, and Sepsis research to improve care

  A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11595454

• Endothelial inflammation memory after sepsis and pneumonia

  A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.

  NIH research Albany Medical College · Albany, United States · NIH-11572337

• Bacterial Biofilm Therapy with a Human Antibody to Help Antibiotics Work Better

  A human antibody drug is being studied to disrupt bacterial biofilms and help standard antibiotics clear infections, especially around implants and catheters, in adults.

  NIH research Trellis Bioscience, INC. · Redwood City, UNITED STATES · NIH-11532353

• A tissue slice model to test treatments for Pneumocystis pneumonia in people with HIV/AIDS

  Researchers are creating a lung-slice model to study Pneumocystis jirovecii pneumonia and test potential treatments using tissue from infected, immunosuppressed mice to better predict what might help people with HIV/AIDS.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11469744

• Measuring respiratory and gut bacteria to predict pneumonia treatment failure

  A project to understand how bacterial load in the lungs and gut changes during and after antibiotics for hospital-acquired and ventilator-associated pneumonia, with the goal of predicting which patients might fail treatment.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11463313

• Better tests and treatments for Pneumocystis (PCP) pneumonia

  Developing more accurate tests and safer treatment options for people with weakened immune systems who get Pneumocystis pneumonia.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11458530

• Glycan signals in neutrophils and pneumonia risk after brain injury

  This grant explores how immune Cells in people with brain injury may become more prone to pneumonia due to changes in sugars on their cells, with the goal of preventing infections.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11451948

• Azithromycin vs doxycycline with beta-lactam in hospitalized adults with pneumonia

  In hospitalized adults with community-acquired pneumonia, this study will compare two antibiotic combinations to see which works better and is safer.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11451639

• Challenging the equivalence of two antibiotics for P. aeruginosa pneumonia (IMPACT study)

  This project compares two common antibiotics, cefepime and piperacillin-tazobactam, to see which works better for treating pneumonia caused by Pseudomonas aeruginosa in ICU patients.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11447595

• Combined immunomodulatory effect of macrolides and corticosteroids in hospitalized CAP patients

  This study looks at whether adding macrolide antibiotics to steroids helps or harms people hospitalized with community-acquired pneumonia (CAP).

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11437358

• Machine learning to map microbiome changes in ventilator-associated pneumonia

  A machine-learning guided study will analyze 16S microbiome data from mechanically ventilated patients to help identify and diagnose ventillator-associated pneumonia earlier.

  NIH research University of New Haven · West Haven, United States · NIH-11424131

• Using oral antibiotics first to treat pneumonia in hospitalized kids

  Aimed at making pneumonia treatment in hospitalized children safer and more comfortable by favoring oral antibiotics when possible instead of IV, to save time, reduce harm, and lower costs.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11415417

• Optimizing antibiotic combos to kill CRAB and CR-Klebsiella pneumoniae in mouse pneumonia models

  This project tests antibiotic combinations in mouse models to rapidly kill stubborn bacterial infections and prevent resistance, with the goal of better treatments for CRAB and CRKP pneumonia.

  NIH research University of Florida · Gainesville, United States · NIH-11413428

• New antibiotic combinations to fight dangerous Acinetobacter and Klebsiella infections

  A multi-year program tests new antibiotic mixes to more effectively treat serious drug-resistant lung infections caused by Acinetobacter baumannii and Klebsiella pneumoniae.

  NIH research University of Florida · Gainesville, United States · NIH-11413415

• Multidimensional view of how regulatory T cells behave in kids with severe viral pneumonia

  A doctor-scientist program aims to understand how regulatory T cells influence recoveries from severe viral pneumonia in children, with results that could lead to better treatments.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11401190

• Regulatory T cells helping lungs recover after severe viral pneumonia

  A study explores how a special type of immune cell, regulatory T cells, helps the lungs heal after severe pneumonia from flu or COVID-19.

  NIH research Northwestern University · Chicago, United States · NIH-11395280

• Targeting Pneumocystis cell-wall enzyme to help people with AIDS-related pneumonia

  A Mayo Clinic team is studying a fungal enzyme, phosphoglucomutase, to see if blocking it can weaken Pneumocystis pneumonia in people with AIDS.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11395141

• Mechanistic modeling of lung immune responses to explain why COVID-19 affects people differently

  A research team at the University of Florida is building personalized computer and lab models to understand why COVID-19 causes different levels of illness in different people.

  NIH research University of Florida · Gainesville, United States · NIH-11386430

• How a common MUC5B gene change leads to scarring in the lungs (UIP)

  Researchers are examining how a common MUC5B gene change alters lung cell gene activity in people with scarring lung diseases like idiopathic pulmonary fibrosis, chronic hypersensitivity pneumonitis, and rheumatoid arthritis–related interstitial lung disease.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11383510

• Pulmonary nerve signals shaping antibody production against pneumonia

  A study to understand how the lungs’ sensory nerves influence the body’s antibody response to pneumonia-causing bacteria.

  NIH research Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, United States · NIH-11381799

• Understanding the sexual cycle of Pneumocystis to find new treatments for HIV-related pneumonia

  A research project at the University of Cincinnati is exploring how Pneumocystis jirovecii completes its life cycle to identify new drug targets for Pneumocystis pneumonia in people with HIV/AIDS.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11380769

• Follistatin-like 1 helps the lungs defend against pneumonia

  This grant explores how a protein called FSTL-1 helps the body fight bacterial pneumonia, with a focus on adults and children and a common resistant bacteria.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11380649

• SSLs: How Staph bacteria dodge our lungs and a potential therapy for pneumonia

  This project looks at how Staphylococcus aureus uses SSLs to avoid our immune system in lung infections and explores a possible treatment to prevent pneumonia.

  NIH research Louisiana State Univ A&m Col Baton Rouge · Baton Rouge, United States · NIH-11378779

• Effective primary care after pneumonia to boost recovery

  A Johns Hopkins team is testing a patient-centered way for primary care to help people recover better in the 6 months after a hospital stay for pneumonia.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11378012

• Biomimetic macrophage-coated nanosponges for deadly hospital pneumonia

  A new, macrophage-membrane wrapped nanoparticle therapy is being tested to help treat pneumonia caused by multidrug‑resistant bacteria in hospitalized patients.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11377015

• Immune proteins made in the lung that may protect against pneumonia

  Looking at whether immune proteins made in the lungs can help people with bacterial pneumonia recover with less lung damage.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11374926

• GNB2 in macrophages helps fight Legionella pneumonia

  A doctor-scientist team will study how a protein called GNB2 helps lung immune cells in fighting Legionella pneumonia.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11368634

• Lung interstitial macrophages and bacterial pneumonia

  This project investigates how certain lung immune cells help protect adults and children from pneumonia after a prior infection.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11368509

• Lung infections and brain health: could lung-made tau affect thinking after critical illness

  A government-funded study will look at whether a protein variant released from the lungs during pneumonia could contribute to thinking and memory problems after serious illness.

  NIH research University of South Alabama · Mobile, United States · NIH-11366492

• A new antibody that blocks eNAMPT to reduce lung injury from hospital- and ventilator-associated pneumonia

  A new antibody treatment is being tested to lessen lung damage from hospital- and ventilator-associated pneumonia and to help prevent the spread of antibiotic resistance.

  NIH research University of Florida · Gainesville, United States · NIH-11366090

• How immune cells and metabolism respond to drug-resistant Klebsiella pneumoniae in the lungs

  This project looks at how carbapenem-resistant Klebsiella pneumoniae in the lungs changes metabolism and immune cells in ways that may let the bacteria persist.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11362212

• Precision dosing for severe pneumonia: optimizing beta-lactam antibiotics

  A study to tailor beta-lactam antibiotic dosing for people with hospital-acquired pneumonia caused by resistant bacteria, aiming to improve treatment success and reduce deaths.

  NIH research Midwestern University · Downers Grove, United States · NIH-11360601

• LOX-1: Understanding Immune Regulation in Pneumonia

  A study at a major university will explore how LOX-1 helps the lungs manage inflammation during pneumonia to support healing.

  NIH research University of Iowa · Iowa City, United States · NIH-11355436

• Optimizing Recovery After Sepsis and Pneumonia

  A patient-facing program aims to improve recovery for people who survived sepsis and pneumonia after hospital discharge.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11337294

• Host-targeted therapy to prevent lung injury from pneumonia-caused sepsis

  A patient-focused look at how boosting the body’s own defenses in the lungs could lessen lung and organ damage during severe pneumonia linked to sepsis from bacteria.

  NIH research Louisiana State Univ A&m Col Baton Rouge · Baton Rouge, United States · NIH-11332285

• Neutrophil responses in pneumococcal pneumonia and acute lung injury

  Researchers will track how neutrophils (a type of white blood cell) change and where they go during pneumococcal pneumonia and acute lung injury to find ways to protect lungs and help recovery.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11330656

• Nosocomial pneumonia and brain blood vessels: a study in people

  This research tests how pneumonia after surgery may damage brain blood vessels and contribute to memory problems in patients.

  NIH research University of South Florida · Tampa, United States · NIH-11330181

• Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold

  A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11325875

• Coordination and data sharing for ARDS, pneumonia, and sepsis research

  A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11325818

• Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing

  A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11321604

Related topics

Quick answers

How many Pneumonia clinical trials are recruiting right now?

72, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 46 countries. The most sites are in United States (18 trials), China (13 trials), Egypt (4 trials), France (4 trials), Italy (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 2: 2, Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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