Clinical trial Recruiting at 1 site Interventional Ages 40 to 50

Rib mobilization to help ventilated pneumonia patients breathe on their own

Official title: Effect of Rib Mobilization on Weaning Parameters From Mechanical Ventilator in Patients With Pneumonia

Run by Cairo University · NCT06835842 · Data updated 2026-11-12

This trial will try rib mobilization versus routine chest physiotherapy to see if it helps adults with pneumonia come off mechanical ventilators sooner.

More Pneumonia trials

Quick facts

Study typeInterventional
Ages40 Years to 50 Years
SexAll
Enrollment60 (estimated)
SponsorCairo University
Academic / other
Locations1 site (Cairo)
StatusRecruiting
StartedMarch 10, 2025
Main results expectedFebruary 10, 2026
Study endsMay 20, 2026
Registry record updatedJuly 10, 2025
Trial IDNCT06835842 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 40–50 with pneumonia who require invasive mechanical ventilation and are hemodynamically stable (SpO2 >85%, FiO2 ≤0.6, PEEP <10 cm H2O, MAP >75 mmHg, urine output >1 mL/kg/h) with GCS >8T are ideal candidates.

Probably not a fit

Patients with unstable hemodynamics, uncontrolled neurological problems, unstable chest wall (multiple rib/vertebral fractures), raised intracranial pressure, undrained pneumothorax, or recent pulmonary surgery are unlikely to benefit or be eligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares a manual rib mobilization technique with routine chest physiotherapy in intubated adults with pneumonia who are receiving invasive mechanical ventilation. Participants meeting stability criteria will receive either rib mobilization or standard chest physiotherapy while clinicians record ventilator weaning parameters such as respiratory rate, tidal volume, and FiO2, plus daily arterial blood gases. Secondary outcomes include length of ICU stay and weaning success rate. The goal is to determine whether adding rib mobilization improves respiratory mechanics and accelerates liberation from the ventilator.

Why it matters

Potential benefit: If successful, rib mobilization could reduce time on the ventilator and shorten ICU stays for patients with pneumonia.

How similar studies have gone: Related chest physiotherapy methods have shown mixed or modest improvements in respiratory mechanics, while direct evidence specifically for rib mobilization in ventilated pneumonia patients is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patient's age ranged from 40- 50 years old from both genders.
2. Diagnosed with pneumonia and need invasive mechanical ventilation support.
3. Stable oxygen saturation (SpO2 more than 85, (FiO2) 0.6 or less, PEEP less than 10 Cm H2O).
4. mean arterial pressure \> 75 mmHg and urine output \> 1 mL/kg/h;
5. Patients with Glasgow coma scale (GCS) \> 8T
6. Unconscious and semi-conscious patients. -

Exclusion Criteria:

1. Unstable hemodynamics
2. Unstable neurological problems e.g. (epileptic seizures -hyperthermia).
3. Unstable chest wall e.g. (multiple rib or vertebral fractures)
4. Increase intracranial pressure (\>20 mmHg for \>5 min).
5. Undrained pneumothorax, recent pulmonary surgery

Where it's running

  • El Galaa Military Hospital
    Cairo, Egypt
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.