Using higher PEEP with mask noninvasive ventilation for people with pneumonia or ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares different levels of positive end-expiratory pressure (PEEP) delivered via mask during noninvasive ventilation for adults with pneumonia or ARDS. Participants meeting oxygenation and consciousness criteria and expected to need NIV for more than 12 hours will receive NIV with specified PEEP settings. The study will track outcomes such as NIV failure, need for intubation, oxygenation measures, and clinical course in the ICU or hospital. The aim is to determine whether higher PEEP improves respiratory status and reduces the rate of progression to invasive mechanical ventilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years
* PaO2/FiO2 ≤300 mmHg or SpO2/FiO2 ≤315（SpO2 ≤97%)
* Anticipated NIV duration \> 12 h
* Preserved consciousness (GCS≥13)

Exclusion Criteria:

* Use of NIV \> 24 h before randomization
* Acute-on-chronic respiratory failure
* Congestive heart failure
* Use of NIV after extubation (within 48 hours)
* Contraindications to NIV (e.g., anatomical malformations, recent pulmonary/esophageal surgery \[within 7 days\])
* Pneumothorax
* NIV intolerance
* Refusal to participate
* Pregnancy
* Need for emergency intubation

Where it's running

• The First Affiliated Hospital of Chongqing Medical University
  Chongqing, China Recruiting

Study contacts

• Study coordinator: Mengyi Ma
• Email: 1062914316@qq.com
• Phone: 86-023-89012680

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.