Optimizing Recovery After Sepsis and Pneumonia
Official title: Optimizing Early Recovery After Sepsis and Pneumonia (OPERAS)
Funded at University of Michigan at Ann Arbor · NIH-11337294 · Data updated 2026-11-12
A patient-facing program aims to improve recovery for people who survived sepsis and pneumonia after hospital discharge.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 16, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $775,930 |
| NIH project number | 1R01NR022600-01 |
| Project ID | NIH-11337294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have survived sepsis and/or pneumonia and are transitioning home from the hospital.
✕Less likely to help
Patients not yet discharged or those with conditions outside the sepsis/pneumonia recovery pathway may not benefit.
What this research studies
This project builds on a nurse-led recovery program to support people who have survived sepsis or pneumonia after leaving the hospital. It tests different system-level care models to help patients stay well during the vulnerable period after discharge. The study uses a cluster-randomized approach to compare how care is organized across communities and hospitals. By focusing on long-term outcomes and readmission risk, it seeks practical improvements that could be adopted in real-world care. If successful, it could help reduce mortality and costly readmissions.
Why it matters
Potential benefit: If successful, the program could reduce readmissions and improve long-term survival and quality of life for sepsis and pneumonia survivors.
How similar studies have gone: Prior STAR nurse navigator programs showed improved outcomes, but continued innovation is needed to optimize recovery.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Taylor, Stephanie P — University of Michigan at Ann Arbor
- Study coordinator: Taylor, Stephanie P
Related research
Other NIH-funded projects on the same topics.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Endothelial inflammation memory after sepsis and pneumonia
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
-
Host-targeted therapy to prevent lung injury from pneumonia-caused sepsis
A patient-focused look at how boosting the body’s own defenses in the lungs could lessen lung and organ damage during severe pneumonia linked to sepsis from bacteria.
-
Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.
-
Coordination and data sharing for ARDS, pneumonia, and sepsis research
A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.
-
Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing
A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.