Multidimensional view of how regulatory T cells behave in kids with severe viral pneumonia
Official title: Multidimensional analysis of the regulatory T cell response in children with severe viral pneumonia
Funded at Lurie Children's Hospital of Chicago · NIH-11401190 · Data updated 2026-11-12
A doctor-scientist program aims to understand how regulatory T cells influence recoveries from severe viral pneumonia in children, with results that could lead to better treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $163,080 |
| NIH project number | 5K08HL176208-03 |
| Project ID | NIH-11401190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children under 5 years old who have experienced severe viral pneumonia and are at risk for lung injury.
✕Less likely to help
The study is focused on understanding mechanisms; direct benefit to individual patients is not guaranteed during the research.
What this research studies
This project uses a mouse model that mirrors how severe viral pneumonia affects very young children to study immune responses over time. It focuses on regulatory T cells and how they control inflammation and repair in the lungs after infection. The research will analyze immune signals, cell interactions, and lung healing processes to identify why children have prolonged lung injury and slower recovery. The ultimate goal is to uncover targets for therapies that could hasten recovery and reduce long-term lung problems in kids who get severe viral pneumonia.
Why it matters
Potential benefit: If successful, findings could guide development of therapies that lessen lung injury and speed recovery in children with severe viral pneumonia.
How similar studies have gone: Previous animal studies showed juvenile mice have prolonged lung inflammation despite viral clearance, supporting the relevance of this model.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Prigge, Andrew — Lurie Children's Hospital of Chicago
- Study coordinator: Prigge, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.