Condition

COPD (Chronic Obstructive Pulmonary Disease) clinical trials and research

• 59Clinical trials
• 47Countries

Newest COPD (Chronic Obstructive Pulmonary Disease) clinical trials

All recruiting trials (59)

• High-Flow Nasal Cannula vs Noninvasive Ventilation in COPD with Hypercapnia

  This study tests whether a high-flow nasal cannula can better support gas exchange and comfort compared with noninvasive ventilation in COPD patients with mild-to-moderate elevated CO2.

  Recruiting Mansoura University · Al Mansurah, Dakahlia Governorate · NCT07854210

• Risk-based lung cancer screening in COPD patients using ML and clinical models

  This study tests whether a PLCOm2012 risk model plus a machine learning model can spot COPD patients at high risk for lung cancer to see if they benefit from low-dose CT screening.

  Recruiting Vejle Hospital · Vejle, Region Syddanmark · NCT07848815

• Biologics for Type 2 Inflammation in Asthma and COPD in Real World

  This real-world study tests whether six biologic drugs can reduce flare-ups and improve symptoms in adults with asthma or COPD treated in routine care in China.

  Recruiting Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT07823842

• Nebulized vs handheld maintenance therapy for COPD patients with limited benefit from inhalers

  This trial tests whether switching to a breath-enhanced nebulizer with similar COPD meds helps people who don’t get enough relief from their current handheld inhalers.

  Recruiting at 2 sites Phase 4 COPD Foundation · Saint Charles, Missouri and 1 other locations · NCT07816835

• New breathing tests to diagnose airway disease in hospital and community settings

  This study tests whether newer breathing tests can correctly diagnose COPD and airway disease as well as standard spirometry, using tests like capnography and oscillometry in hospital and community settings.

  Recruiting University Hospital Southampton NHS Foundation Trust · Andover, Hampshire and 1 other locations · NCT07798596

• Tele-pulmonary rehab after COPD hospitalization

  A tele-rehabilitation program is being tested to see if it helps people with COPD recover after being hospitalized for an acute exacerbation.

  Recruiting North District Hospital · Hong Kong · NCT07762157

• Can a vibroacoustic device help COPD patients get more sputum when they inhale saline mist

  This study tests whether adding a vibroacoustic device during induced sputum collection helps COPD patients produce more sputum.

  Recruiting Fraunhofer-Institute of Toxicology and Experimental Medicine · Hanover, Lower Saxony · NCT07751705

• Balance training after pulmonary rehab for COPD to help steadiness and reduce falls

  A COPD-focused balance training program called Sport4Steadiness is being tested to see if people with COPD will accept it and if the study processes work well.

  Recruiting at 3 sites Teesside University · Middlesbrough and 2 other locations · NCT07750821

• MoblO2 for activity-related oxygen delivery in COPD and ILD

  This study tests whether the MoblO2 device, when attached to a patient’s oxygen tanks, can automatically control oxygen flow during activity to improve how COPD or ILD patients feel and function.

  Recruiting Minnesota HealthSolutions · Denver, Colorado · NCT07704567

• Tele-Pulmonary Rehabilitation for COPD in Peripheral Areas

  This study tests whether a group tele-rehab program for COPD patients living in peripheral areas helps people start and stick with pulmonary rehabilitation better than usual referral to in-person PR.

  Recruiting Tel-Aviv Sourasky Medical Center · Tel Aviv · NCT07666854

• Tele-Pulmonary Rehabilitation for Chronic Lung Diseases

  This study tests whether a remote tele-rehabilitation program helps people with chronic lung diseases start and stick with pulmonary rehab better than usual center-based care.

  Recruiting at 2 sites Tel-Aviv Sourasky Medical Center · Ashkelon and 1 other locations · NCT07666841

• Dose-finding study of WIN378 for moderate to severe COPD

  This study tests different doses of WIN378 to see if it helps adults with moderate to severe COPD who are already on COPD therapy, by looking at safety and how the body uses the medicine.

  Recruiting at 32 sites Phase 2 Windward Bio · Los Angeles, California and 31 other locations · NCT07646587

• Dupilumab in COPD: Real-world Registry of Outcomes

  This registry tests how dupilumab works for COPD patients in everyday care and whether it lowers flare-ups and improves lung function and quality of life.

  Recruiting at 7 sites Sanofi · Indianapolis, Indiana and 6 other locations · NCT07612878

• Isoinertial training for people with COPD

  This study tests whether an isoinertial training program can improve muscle strength and functional capacity in adults with moderate to severe COPD.

  Recruiting at 2 sites Universidad Manuela Beltrán · Bogotá, Bogotá, DC and 1 other locations · NCT07605117

• Biomarker patterns in ACS patients with pneumonia and COPD after flu vaccination

  This study tests whether certain blood biomarkers change in people with acute coronary syndrome who also have pneumonia and COPD, and whether flu vaccination affects those biomarker levels.

  Recruiting Phase 3 University of Brawijaya · Malang, East Java · NCT07604103

• See if chest CT and biological data can tell asthma from COPD and predict treatment response

  Researchers will test whether combining chest CT measurements with biological data can distinguish asthma from COPD and predict how patients will respond to standard treatments.

  Recruiting at 2 sites Korea University Guro Hospital · Seoul, Dongjak-gu and 1 other locations · NCT07602192

• Breathing better with HSK39004: a inhaled medicine tested in COPD patients

  This phase 3 trial tests whether inhaled HSK39004 powder helps people with COPD improve breathing compared with a placebo.

  Recruiting Phase 3 Haisco Pharmaceutical Group Co., Ltd. · Beijing, Beijing Municipality · NCT07583849

• Enhanced COPD care for people being checked for lung cancer

  This project will test whether finding and treating COPD early in people being checked for possible lung cancer helps symptoms, lung function, and overall care.

  Recruiting Region of Southern Denmark · Vejle · NCT07543601

• Enhanced COPD care for people being checked for lung cancer

  This project will test whether finding and treating COPD early in people being checked for possible lung cancer helps symptoms, lung function, and overall care.

  Recruiting Region of Southern Denmark · Vejle · NCT07543601

• Using lung cancer screening CT scans to find COPD (MAP2)

  This project will use lung cancer screening CT scans and spirometry in current and former smokers aged 50–80 with at least 20 pack-years to see if CT findings can identify people who have COPD.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07482475

• Safety and performance of the INBENTUS VERSATILE ventilator in adults on invasive mechanical ventilation

  This trial will test whether the INBENTUS VERSATILE ventilator is safe and performs well in adults who need assisted or controlled invasive mechanical ventilation and short-term weaning.

  Recruiting Iconic Solutions By Murcia SL · Murcia · NCT07432191

• Pulmonary and Total Blood Volume in COPD: Do COPD patients have lower pulmonary blood volume relative to total blood volume than healthy adults?

  This study tests whether people with COPD have a lower ratio of pulmonary blood volume to total blood volume compared with healthy adults of similar age, sex, and height.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07428785

• Does nighttime hypoventilation predict long-term benefit from non-invasive ventilation in people with hypercapnic COPD?

  This project tests whether nighttime hypoventilation can identify people with COPD and high CO2 who will have larger drops in arterial CO2 after 6 and 12 months on non-invasive ventilation.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT07414108

• Real-world effectiveness of the extra-fine BDP/FF/GB triple inhaler in Brazilian COPD patients

  This project will test whether the extra-fine BDP/FF/GB triple inhaler (Trimbow) helps adults in Brazil with severe or very severe COPD feel better and have fewer flare-ups.

  Recruiting Chiesi Farmaceutici S.p.A. · São Paulo, São Paulo · NCT07406048

• Health Haven: Comprehensive maintenance program for COPD in Lleida (NAPOLEON)

  This 12-month randomized trial will test whether a supervised, multidimensional maintenance pulmonary rehabilitation program helps adults with moderate to severe COPD keep symptom relief and quality-of-life gains after their initial rehab.

  Recruiting at 2 sites Institut de Recerca Biomèdica de Lleida · Lleida, Catalonia and 1 other locations · NCT07394712

• Heart failure with preserved ejection fraction in people with COPD: clinical course and prognosis

  This project will see how often HFpEF appears in people aged 50–70 hospitalized with COPD and whether having HFpEF changes their symptoms, exercise capacity, and prognosis.

  Recruiting at 2 sites National Medical Research Center for Therapy and Preventive Medicine · Kazan' and 1 other locations · NCT07375433

• JKN2403 for adults with moderate-to-severe COPD

  This trial will try an oral medicine called JKN2403 to see if it reduces flare-ups and improves symptoms and quality of life in adults with moderate-to-severe COPD.

  Recruiting Phase 2 Joincare Pharmaceutical Group Industry Co., Ltd · Guangzhou, Guangdong · NCT07351734

• Posture correction plus resistive breathing muscle training for COPD with forward head posture

  This study will try posture exercises together with resistive inspiratory and expiratory breathing training to help people aged 40–60 with mild-to-moderate COPD and forward head posture breathe better.

  Recruiting Riphah International University · Lahore · NCT07293429

• Inhaled RB042 in healthy adults and adult smokers

  This trial will try an inhaled medicine called RB042 to see if it is safe and how the body handles it in healthy adults and current adult smokers.

  Recruiting Phase 1 Atisama Therapeutics · Nedlands, Western Australia · NCT07285122

• Predicting COPD flare-ups from data recorded by home non-invasive ventilators

  This will try to use an AI program to find early signs of worsening COPD from data collected by people’s home non-invasive ventilators.

  Recruiting Corporacion Parc Tauli · Sabadell, Barcelona · NCT07267104

• Blood Flow Restriction During Low-Intensity Exercise in COPD

  This trial tests whether adding blood flow restriction to low‑intensity aerobic exercise within a standard pulmonary rehab program improves inflammation, oxygen levels, exercise capacity, and lung function in people with COPD.

  Recruiting Istinye University · Istanbul · NCT07261293

• New handheld breathing device test for asthma or COPD diagnosis

  A handheld device called the N-Tidal Handset is used for 75 seconds to see if a quick breathing test can accurately diagnose asthma or COPD in adults referred for routine lung testing.

  Recruiting Liverpool Heart and Chest Hospital NHS Foundation Trust · Liverpool, Merseyside · NCT07253883

• Nebulizer versus dry-powder inhaler long-acting bronchodilator treatment for COPD

  This study will test whether a nebulized long-acting bronchodilator combination helps people with symptomatic COPD and air trapping breathe better than the same medicines given by a dry powder inhaler.

  Recruiting Phase 4 University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07133880

• Pulmonary rehabilitation in underground salt chambers for people with COPD

  This program will try pulmonary rehabilitation sessions inside underground salt chambers to see if people with COPD breathe better, feel less symptomatic, and improve their fitness.

  Recruiting University School of Physical Education, Krakow, Poland · Krakow, Małopolska · NCT07122544

• Follow-up after COPD exacerbation

  This project will try an AI-enabled workflow tool (Viz COPD) to see if it increases respiratory specialist follow-up and improves outcomes after a COPD flare-up in patients seen in the emergency department.

  Recruiting at 3 sites Viz.ai, Inc. · Park Ridge, Illinois and 4 other locations · NCT07118306

• Multiomics analysis of how common colds cause COPD flare-ups

  The team will intentionally infect people with moderate COPD and healthy volunteers with a common cold virus to see if detailed blood, lung, and genetic tests can find new targets to prevent or lessen COPD flare-ups.

  Recruiting Imperial College London · London · NCT07112235

• Paramedic home visits for sudden COPD flare-ups (PEACE)

  This program will try sending community paramedics, guided by remote physicians, to treat adults with COPD at home during sudden flare-ups to reduce emergency visits.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT07072039

• Pulsed electric field ablation for chronic bronchitis in COPD

  This trial will test whether pulsed electric field ablation can reduce symptoms in adults with moderate to severe chronic bronchitis from COPD.

  Recruiting Suzhou Hengruihongyuan Medical Technology Co. LTD · Hefei, Anui and 12 other locations · NCT07068438

• Inhaled Treprostinil (Tyvaso) for people with COPD and low oxygen

  This study will see if inhaled Treprostinil (Tyvaso) can increase lung blood flow and oxygen delivery in adults with COPD who have low oxygen levels.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT07037836

• Photon-counting CT for lung imaging in people with COPD

  This project will test whether photon-counting CT scans can produce more accurate and reproducible measurements of emphysema and airway changes in people with COPD.

  Recruiting Duke University · Durham, North Carolina · NCT07031336

• Graduated response with enhanced support for people with advanced COPD

  This project will try a stepped enhanced-support program—regular needs checks, advance care planning, and cross-sector virtual conferences—for people with advanced COPD to see if it improves quality of life and use of health services.

  Recruiting Copenhagen University Hospital, Hvidovre · Hvidovre · NCT06967324

• Digital inhaler management versus inspiratory muscle training for COPD

  This trial will try digital inhaled therapy management and inspiratory muscle training, alone or together, to see if they cut exacerbations and hospital visits in people aged 40 and older with symptomatic moderate-to-severe COPD.

  Recruiting at 9 sites Sir Run Run Shaw Hospital · Hangzhou, Zhejiang and 8 other locations · NCT06958666

• Virtual rehabilitation program for COPD patients

  This study is testing a digital rehab program for people with COPD to see if it helps them breathe better, exercise more, and improve their overall quality of life.

  Recruiting Turku University Hospital · Turku, Southwest Finland and 1 other locations · NCT06915740

• Psilocybin therapy for depression and existential distress in people with COPD, ALS, MS, or atypical Parkinson disease

  This trial will test whether psilocybin therapy can reduce depression and psychological distress in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least six months expected life.

  Recruiting at 4 sites Phase 2 University Medical Center Groningen · Prague and 3 other locations · NCT06782724

• Evaluating COPD in the Brazilian population

  This study is trying to learn more about how severe COPD affects people in different parts of Brazil by following patients for a year to see how their condition changes.

  Recruiting at 10 sites AstraZeneca · Aparecida de Goiânia and 9 other locations · NCT06780046

• Tracking severe and very severe COPD across Brazil

  This project will follow people with severe or very severe COPD in Brazil for one year to see which groups have higher risk of exacerbations, hospital stays, heart problems, or death.

  Recruiting Hospital Israelita Albert Einstein · São Paulo, São Paulo · NCT06724315

• Probiotics for improving pulmonary rehabilitation in COPD patients

  This study is testing if taking probiotics can help people with COPD feel better and improve their results during pulmonary rehabilitation.

  Recruiting Fu Jen Catholic University · New Taipei City · NCT06717659

• Effects of Aronia Berry on Inflammation in COPD Patients

  This study is testing if eating freeze-dried aronia berries can help reduce inflammation in people with COPD.

  Recruiting Amasya University · Istanbul, Zeytinburnu · NCT06702696

• Assessing breathing patterns during non-invasive ventilation

  This study is testing which of two different masks used in non-invasive ventilation helps people with COPD and Obesity Hypoventilation Syndrome breathe better and feel more comfortable.

  Recruiting Fisher and Paykel Healthcare · Auckland · NCT06682286

• Respiratory rehabilitation to improve sleep in COPD

  This trial will test whether a respiratory rehabilitation program can improve sleep quality measured by overnight polysomnography in people aged 50 and older with stable COPD.

  Recruiting University Hospital, Rouen · Amiens and 3 other locations · NCT06677268

• Endobronchial thermal liquid ablation for treating emphysema

  This study is testing a new treatment called endobronchial thermal liquid ablation to see if it can safely help people with severe emphysema breathe better and improve their quality of life.

  Recruiting at 2 sites Morair Medtech, LLC · Vienna, Austria and 6 other locations · NCT06655428

• French QASCI questionnaire for caregivers of people with COPD

  This project will test the French version of the QASCI questionnaire to see if it works well for caregivers of people with COPD.

  Recruiting at 2 sites University Hospital, Brest · Brest and 1 other locations · NCT06652204

• How viral infections affect people with chronic lung disease

  This study will test if respiratory viruses trigger flare-ups and change immune responses in adults with COPD or bronchiectasis.

  Recruiting Imperial College London · London · NCT06625944

• Routine versus on-demand ECMO during lung transplant

  This trial tests whether using ECMO routinely during lung transplant or only when needed leads to fewer complications for people having a lung transplant.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Edmonton, Alberta and 3 other locations · NCT06615492

• Effects of Vibration Exercises on COPD Patients

  This study is testing if different types of vibration exercises can help people with COPD improve their muscle strength, endurance, and overall quality of life.

  Recruiting Taipei Medical University · Taipei, Wenshan Dist · NCT06413524

• Digital follow-up program for COPD patients in primary healthcare

  This study tests a digital program that helps people with COPD manage their condition better with support from primary care nurses to see if it improves their quality of life.

  Recruiting Western Norway University of Applied Sciences · Bergen, Norway · NCT06401512

• Evaluating a new inhaler for COPD patients

  This study is testing a new inhaler for people with COPD to see if it helps improve their lung health compared to a standard treatment.

  Recruiting at 677 sites Phase 3 AstraZeneca · Athens, Alabama and 921 other locations · NCT06283966

• Improving outcomes for vulnerable COPD patients through a wellness program

  This study is testing a 10-week wellness program for people with COPD in underserved communities to see if it helps them feel better compared to regular care.

  Recruiting at 3 sites University of California, San Francisco · San Francisco, California and 2 other locations · NCT05572632

• Dietary intervention to improve COPD outcomes

  This study is testing if a home food delivery program that boosts omega-3 fatty acids can help people with COPD breathe better and feel healthier.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05297279

Related topics

Quick answers

How many COPD (Chronic Obstructive Pulmonary Disease) clinical trials are recruiting right now?

59, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 47 countries. The most sites are in United States (12 trials), Denmark (7 trials), China (6 trials), United Kingdom (6 trials), Brazil (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 3, Phase 4: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →