Infusion regimen of piperacillin-tazobactam for pneumonia in older adults
Official title: Model-Guided Dose Optimization vs. Empirical Dosing of Piperacillin-Tazobactam in the Treatment of Pneumonia in Elderly Patients: A Study on Superiority
Run by Shandong University · NCT06972537 · Data updated 2026-11-12
This study tests which way of giving an antibiotic for pneumonia works better for older adults, either every 6 hours or every 8 hours, to help them recover more effectively.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years to 100 Years |
| Sex | All |
| Enrollment | 42 (estimated) |
| Sponsor | Shandong University Academic / other |
| Locations | 1 site (Jinan, Shandong) |
| Status | Recruiting |
| Started | July 24, 2024 |
| Main results expected | September 30, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | May 15, 2025 |
| Trial ID | NCT06972537 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients aged 65 and older who have a clinical diagnosis of pneumonia and are receiving intravenous piperacillin-tazobactam treatment.
✕Probably not a fit
Patients with a history of allergy to β-lactam antibiotics, those undergoing continuous renal replacement therapy, or individuals with severe organ dysfunction or malignant tumors may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the optimal infusion regimen of piperacillin-tazobactam, a broad-spectrum antibiotic, in patients aged 65 and older diagnosed with pneumonia. It compares two different infusion schedules: every 6 hours for 4 hours versus every 8 hours for 3 hours, aiming to determine which regimen achieves better drug concentration compliance. The research is motivated by the high incidence and mortality rates of pneumonia in the elderly and seeks to provide evidence that could enhance treatment protocols for this vulnerable population.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment outcomes for elderly patients with pneumonia by optimizing antibiotic administration.
How similar studies have gone: While there is limited research specifically targeting infusion regimens in the elderly population, similar studies on antibiotic dosing strategies have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Age must be greater than 65 years Clinical diagnosis of Pneumonia Receiving intravenous piperacillin-tazobactam treatment Exclusion Criteria: History of allergy to β-lactam antibiotics Continuous renal replacement therapy, severe organ dysfunction Malignant tumor disease
Where it's running
-
Second hospital of Shandong university
Jinan, Shandong, China Recruiting
Study contacts
- Study coordinator: Wei Zhao, Ph.D
- Email: zhao4wei2@hotmail.com
- Phone: 86053188383308
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Respiratory Physiotherapy in Critically Ill Pneumonia Patients
This study tests whether a structured breathing and chest therapy program can change inflammatory biomarkers in adults with pneumonia in the ICU compared to usual care.
-
AI-powered CT help to guide pneumonia care
A multicenter trial tests whether using a chest CT–based AI report to guide care reduces death or need for new organ support in adults with pneumonia.
-
Wintergreen oil inhalation for shortness of breath in pneumonia patients
Hospitals will test whether inhaling wintergreen essential oil helps relieve dyspnea in adults with pneumonia.
-
Optimising Antibiotic Use for Paediatric LRTIs in Africa
This study tests whether using point-of-care CRP tests together with the PREPARE score can safely reduce antibiotic use in infants aged 2–24 months with lower respiratory infections in a Johannesburg hospital.
-
Buteyko Breathing vs Incentive Spirometry for Smog-Induced Pneumonia
We’re testing whether the Buteyko Breathing Technique can improve oxygen levels and breathe easier for adults with smog-related pneumonia compared to incentive spirometry.
-
FUNGAL-P: A score to spot fungal pneumonia early in adults with pneumonia
Aimed at adults with pneumonia, this study tests a new score to help identify fungal pneumonia sooner so doctors can test appropriately and start antifungal treatment when needed.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.