Combined immunomodulatory effect of macrolides and corticosteroids in hospitalized CAP patients
Official title: Evaluating the Combined Immunomodulatory Effect of Macrolides and Corticosteroids in Hospitalized Patients with Community Acquired Pneumonia (CAP)
Funded at Mayo Clinic Rochester · NIH-11437358 · Data updated 2026-11-12
This study looks at whether adding macrolide antibiotics to steroids helps or harms people hospitalized with community-acquired pneumonia (CAP).
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $240,600 |
| NIH project number | 1R03HL187208-01 |
| Project ID | NIH-11437358 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults hospitalized with community-acquired pneumonia who are candidates for macrolide-based antibiotic therapy and have no contraindications to corticosteroids.
✕Less likely to help
Patients who do not respond to anti-inflammatory strategies or have conditions where corticosteroids are unsuitable may derive little or no benefit.
What this research studies
People with community-acquired pneumonia often have excessive inflammation that antibiotics alone may not fully control. The project examines how macrolide antibiotics, known for their immune effects, work when given with corticosteroids in hospital settings. Researchers will measure inflammatory markers and track clinical outcomes to see if the combination improves recovery or introduces new risks. The goal is to clarify whether this dual approach can optimize treatment for CAP patients by tailoring anti-inflammatory strategies to the patient’s response.
Why it matters
Potential benefit: If successful, the approach could improve recovery, shorten hospital stays, and reduce inflammatory complications for CAP patients.
How similar studies have gone: Previous studies suggest potential benefits of macrolides or steroids in CAP, but combined use has limited and mixed evidence.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Odeyemi, Yewande — Mayo Clinic Rochester
- Study coordinator: Odeyemi, Yewande
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.