Sulbactam-Durlobactam for CRAB infections in real-world care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational cohort study analyzes adults hospitalized with CRAB infections to see how sulbactam-durlobactam performs in real clinical practice. Patients are grouped by whether they receive sulbactam-durlobactam or alternative anti-CRAB regimens during the same period. Primary outcomes include 28-day all-cause mortality and clinical failure, with secondary outcomes such as microbiological clearance, recurrence, ICU and hospital length of stay, duration of ventilation, and adverse events. To reduce bias, the study uses propensity score matching and inverse probability weighting, along with multivariable regression and landmark analysis. A nested TDM sub-cohort will examine drug exposure and outcomes using PK/PD modeling.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years.
* Hospitalized patients receiving anti-CRAB antimicrobial therapy, including:

  1. patients with confirmed carbapenem-resistant Acinetobacter baumannii (CRAB) infection based on microbiological testing in combination with clinical evidence of infection; or
  2. transplant recipients with donor-derived CRAB colonization or infection who receive early targeted antimicrobial therapy.
* Treatment initiation time can be clearly determined.
* Availability of clinical outcome data.

Exclusion Criteria:

* Colonization without evidence of active infection.
* Missing key clinical data.
* Inability to determine treatment initiation time.
* Pregnancy or lactation.
* Patients considered unsuitable by investigators.

Where it's running

• Sichuan Provincial People's Hospital
  Chengdu, Sichuan, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.