Wintergreen oil inhalation for shortness of breath in pneumonia patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, non-blinded study will enroll 84 hospitalized pneumonia patients and assign them to seven groups to receive different inhaled preparations, including wintergreen oil at several concentrations, a placebo, a positive control, or routine care. Inhalations occur three times daily for three days, using a small amount of oil on gauze held near the nose for brief breaths. Researchers will measure breathing effort, oxygen levels, blood lactate, lung function, lab markers, and patient-reported comfort before and after the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Primary diagnosis of pneumonia with dyspnea symptoms.
2. Admitted with ICD-10 diagnosis codes: Influenza and viral pneumonia (J10-J12), Bacterial pneumonia (J13-J15), Other infectious agents (J16-J17), or Unspecified organism pneumonia (J18.9).
3. Aged 18 to 90 years.
4. Clear consciousness (Glasgow Coma Scale: 15) with normal mental and behavioral capacity.
5. Able to communicate verbally or non-verbally and comprehend Mandarin or Taiwanese.

Exclusion Criteria:

1. Dementia (including Alzheimer's disease, Parkinson's disease, etc.).
2. Acute psychiatric symptoms precluding communication.
3. Known allergy or hypersensitivity to salicylates, aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs).
4. Anosmia or severe nasal diseases.
5. Pregnant or lactating women.
6. Currently receiving non-invasive positive pressure ventilation (NIPPV, BiPAP), high-flow nasal cannula (HFNC), or oxygen masks (such as Simple mask, Non-rebreathing mask).
7. History of asthma.
8. History of very severe chronic obstructive pulmonary disease (COPD): GOLD stage 4 (FEV1 \< 30% predicted).

Where it's running

• Far Eastern Memorial Hospital
  New Taipei City, Taipei, Taiwan Recruiting

Study contacts

• Principal investigator: Shu-Ding Lin — Far Eastern Memorial Hospital
• Study coordinator: Shu-Ding Lin
• Email: lin102510015@gmail.com
• Phone: +886978291152

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.