Imaging lung function in patients who received stem cell transplants
Official title: Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment
Run by M.D. Anderson Cancer Center · NCT05041140 · Data updated 2026-11-12
This study is testing a special type of MRI to see how well the lungs are working in adults who have had a stem cell transplant and are having breathing problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | M.D. Anderson Cancer Center Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | August 14, 2024 |
| Main results expected | July 20, 2027 |
| Study ends | July 20, 2027 |
| Registry record updated | August 25, 2026 |
| Trial ID | NCT05041140 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adult patients who have received an allogeneic hematopoietic cell transplant and are experiencing bronchiolitis obliterans syndrome or related pulmonary impairments.
✕Probably not a fit
Patients with active pulmonary infections, severe claustrophobia, or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the use of hyperpolarized 129-Xenon magnetic resonance imaging (129-XeMRI) to assess lung function in adult patients who have undergone allogeneic hematopoietic cell transplantation and are experiencing pulmonary impairment. The study will correlate 129-Xenon imaging results with traditional lung function tests and CT scans to better understand the condition of bronchiolitis obliterans syndrome and its progression. Additionally, it will include a healthy control group for technical calibration of the imaging technology.
Why it matters
Potential benefit: If successful, this study could provide a non-invasive method to better diagnose and monitor lung complications in stem cell transplant recipients.
How similar studies have gone: While the use of hyperpolarized gas imaging is a novel approach, similar imaging techniques have shown promise in assessing lung function in other populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Allo-HCT recipients who are at least 18 years of age and have BOS (n=10 patients), BOS 0p (n = 10 patients), or cGVHD of a non-lung organ without evidence of pulmonary impairment (n = 5 patients). Healthy Cohort - Inclusion Criteria: We will perform only XeMRI imaging on 10 healthy adult (18 years and older) volunteers with no medical issues for technical calibration of the XeMRI technology. Members of the study team may serve as healthy volunteers if they have no prior history of lung disease. These data will not be included as part of the analysis. Exclusion Criteria: 1. Participants unable to follow up at MD Anderson for routine clinical care 2. Inability or unwillingness to give informed consent 3. Relapsed disease or life expectancy less than 6 months at time of enrollment 4. Severe claustrophobia precluding MRI imaging 5. Active pulmonary infection 6. Pregnant women
Where it's running
-
M D Anderson Cancer Center
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Ajay Sheshadri — M.D. Anderson Cancer Center
- Study coordinator: Ajay Sheshadri
- Email: asheshadri@mdanderson.org
- Phone: (713) 563-1987
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.