Emergency PanorOmics Wide Association for Respiratory Infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop an emergency PanorOmics Wide Association Study (ePWAS) to rapidly characterize known and novel infectious diseases in adults presenting to emergency departments with suspected acute respiratory infections. It involves creating a biobank for collecting clinical samples and data, which will be used for targeted research to discover new diagnostics, prognostics, and therapeutics. The study addresses the urgent need for improved preparedness and response to respiratory infectious diseases, particularly in light of the COVID-19 pandemic.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients eligible for enrolment include:

With reference to previous inclusion criteria are:

* Adults ≥18 years of age; AND
* Suspected, acute, community-acquired, respiratory, infectious disease (scaRID)\*; AND
* Informed consent.

Note: scaRID is defined according to ALL three criteria:

1. Community acquired (not hospitalised for \<28 days); AND
2. Acute infection (defined as symptom onset \<8 days and any ONE of reported fever or chills or aural temperature \>37.5°C or hypothermia or leucocytosis or leucopaenia or new altered mental status); AND
3. Probable respiratory infection - According to any ONE of:

   1. new cough or new sputum production or
   2. chest pain or
   3. dyspnoea or
   4. tachypnoea or
   5. abnormal lung examination or
   6. respiratory failure; or
   7. physician's judgment (presenting with systemic or gastrointestinal symptoms).

Control subjects will be drawn from two groups:

* The worried well - adult patients with a National Early Warning Score (NEWS) \<3 and a temperature \<37.5°C.
* Relatives or accompanying friends with no acute illness.

Exclusion Criteria:

* Refusal of consent;
* Recent hospitalisation (\<28 days);
* Enrolled in another clinical trial
* Cellulitis;
* Skin or orthopaedic infections;
* Urinary tract infection;
* Acute abdominal sepsis;
* Sexual transmitted disease;
* Human immunodeficiency virus (HIV) infection;
* Immunocompromised/potential neutropenic fever;
* Solid organ or haematopoietic stem-cell transplant within the previous 90 days;
* Active graft-versus-host disease or bronchiolitis obliterans;
* Severe traveller's disease requiring urgent hospitalisation and management including malaria, dengue, typhoid and other rickettsial diseases;
* Stroke;
* Toxidrome;
* Non-organic acute psychosis.

Where it's running

• Hong Kong University
  Hong Kong, China Recruiting

Study contacts

• Principal investigator: Timothy H Rainer, MD — The University of Hong Kong
• Study coordinator: Timothy H Rainer, MD
• Email: thrainer@hku.hk
• Phone: +852 39176846

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.