Examining Lung Proteins in Patients with Pneumonia
Official title: Biomarkers and Protein Mass Expression Profiles in Bronchoalveolar Lavage From Patients With Lung Infiltrates
Run by National Institutes of Health Clinical Center (CC) · NCT00077909 · Data updated 2026-11-12
This study is testing lung fluid samples from pneumonia patients to see if certain proteins can help identify the causes of their lung issues and improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 3 Years to 99 Years |
| Sex | All |
| Enrollment | 750 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | February 20, 2004 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT00077909 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients undergoing diagnostic bronchoscopy for clinical reasons who consent to participate in the study.
✕Probably not a fit
Patients who do not wish to participate in the proteomic analysis or chart review will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study analyzes bronchoalveolar lavage (BAL) fluid from patients with pneumonia to identify protein and peptide patterns associated with different types of pulmonary diseases. By using advanced proteomic techniques, the research aims to discover biomarkers that can help determine the causes of lung inflammation and infection. Patients undergoing bronchoscopy at the NIH Clinical Center will provide BAL samples, which will be analyzed to improve understanding of the host response to pneumonia and potentially guide treatment options.
Why it matters
Potential benefit: If successful, this study could lead to the identification of specific biomarkers that improve diagnosis and treatment of pneumonia.
How similar studies have gone: While similar studies have explored biomarkers in pneumonia, this approach using advanced proteomic analysis is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: * All eligible patients undergoing diagnostic bronchoscopy who provide consent for proteomic analysis of BAL fluid supernatant and chart review of patient characteristics will be included in this study. * A parent/guardian may provide consent for a child age 17 or under and a Legally Authorized Representative (LAR) may provide consent for adults unable to consent. EXCLUSION CRITERIA: Patients undergoing bronchoscopy but not wanting to participate with either the chart review or the proteomic analysis of BAL fluid supernatant will be excluded.
Where it's running
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National Institutes of Health Clinical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Anthony F Suffredini, M.D. — National Institutes of Health Clinical Center (CC)
- Study coordinator: Gloria Y Pastor, C.R.N.P.
- Email: pastorg@cc.nih.gov
- Phone: (301) 402-3484
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Other studies for the same condition or treatment. Recruiting studies are listed first.
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FUNGAL-P: A score to spot fungal pneumonia early in adults with pneumonia
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.