OLE airway clearance with EIT monitoring for ICU patients with pneumonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults in the ICU with confirmed pulmonary infection and high sputum output will receive OLE airway clearance therapy while lung ventilation is monitored noninvasively by electrical impedance tomography (EIT). The primary outcome is peak cough flow (CPF) to measure ability to clear secretions, and the study will compare responses across patients with different causes of atelectasis. Patients on simple oxygen support (nasal cannula or face mask) and able to consent or with a legal representative will be enrolled; those requiring mechanical ventilation or vasopressors are excluded. The trial aims to link EIT-derived ventilation patterns with clinical cough performance to identify who benefits most from OLE therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Clearly diagnosed with pulmonary infection in the ICU, confirmed by microbiological tests (sputum culture, blood culture, etc.) or imaging tests (chest CT, chest X-ray);
2. Age ≥ 18 years;
3. Respiratory support is oxygen therapy (nasal cannula or face mask oxygen therapy);
4. Sputum volume \> 30 ml/day;
5. The patient or their legal representative signs the informed consent form.

Exclusion Criteria:

1. Pregnant or breastfeeding women;
2. Presence of respiratory or circulatory failure (requiring mechanical ventilation or vasopressor support to maintain circulation);
3. Untreated tension pneumothorax;
4. Body Mass Index (BMI) exceeding 50 kg/m²;
5. Rib deformities or severe thoracic deformities;
6. Contraindications for the use of EIT (such as implanted automatic cardiac defibrillators, acute chest trauma, subcutaneous implanted pumps, etc.);
7. Early withdrawal from the study or incomplete clinical data.

Where it's running

• Chinese PLA Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: kaifei wang, Doctor
• Email: zhaoying301301@163.com
• Phone: +86 10 55499330

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.