LOX-1: Understanding Immune Regulation in Pneumonia
Official title: Establishing Mechanisms of LOX-1-Dependent Immune Regulation During Pneumonia
Funded at University of Iowa · NIH-11355436 · Data updated 2026-11-12
A study at a major university will explore how LOX-1 helps the lungs manage inflammation during pneumonia to support healing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 22, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL159258-05 |
| Project ID | NIH-11355436 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with pneumonia or ARDS, including adults, who may benefit from advances in therapies affecting LOX-1 pathways.
✕Less likely to help
Patients without pneumonia or ARDS are unlikely to directly benefit from this basic/translational work.
What this research studies
This project investigates how the LOX-1 receptor influences the immune response and tissue repair in pneumonia, focusing on lung cells like alveolar macrophages. Researchers will use mouse models of pneumonia to see how LOX-1 affects inflammation and edema, aiming to identify pathways that promote recovery. The work could point to new ways to support patients as they regain lung function after infection.
Why it matters
Potential benefit: If successful, the findings could lead to new strategies that speed recovery and reduce lung injury for people with pneumonia and ARDS.
How similar studies have gone: Previous research shows LOX-1 has measurable effects on lung inflammation and repair in animal models, suggesting potential but needing confirmation in humans.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Korkmaz, Filiz — University of Iowa
- Study coordinator: Korkmaz, Filiz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.